68104-71-2Relevant academic research and scientific papers
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents
Sun, Wen-Xue,Ji, Ya-Jing,Wan, Yun,Han, Hong-Wei,Lin, Hong-Yan,Lu, Gui-Hua,Qi, Jin-Liang,Wang, Xiao-Ming,Yang, Yong-Hua
, p. 4066 - 4074 (2017)
In this paper, a series of podophyllotoxin piperazine acetate ester derivatives were synthesized and investigated due to their antiproliferation activity on different human cancer cell lines. Among the congeners, C5 manifested prominent cytotoxicity towar
Microwave-Assisted Synthesis, Antioxidant, and Antimicrobial Evaluation of Piperazine-Azole-Fluoroquinolone Based 1,2,4-Triazole Derivatives
Basoglu Ozdemir, Serap,Demirbas, Neslihan,Demirbas, Ahmet,Ayaz, Faik Ahmet,?olak, Nesrin
, p. 2744 - 2759 (2018/10/25)
Azole derivatives (10a–f) obtained starting from 1-(4-fluorohenyl)piperazine were converted to the corresponding Mannich bases (7a–d, 12a,b, and 16a,b) containing β-lactame or flouroquinolone core via a one-pot three-component reaction. The synthesis of c
INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE
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Paragraph 00285, (2018/09/11)
Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic, cardiovascular, fibrotic, autoimmune/chronic inflammatory diseases, cystic fibrosis, various cancers, neurodegenerative diseases, lipid storage disorders, and ischemia/reperfusion injury, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.
