68116-79-0Relevant academic research and scientific papers
Interleukin-4 gene expression inhibitors
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, (2008/06/13)
This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R1, R2 and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
HALOSILANES IN THE SYNTHESIS OF N-(HALOMETHYL) DERIVATIVES OF LACTAMS, N-METHYLCARBOXAMIDES, AND IMIDES
Orlova, N.A.,Shipov, A.G.,Savost'yanova, I.A.,Baukov, Yu.I.
, p. 1875 - 1881 (2007/10/02)
Methods are proposed for the synthesis of N-(halomethyl) derivatives of lactams, N-methylcarboxamides, and imides with the use of the paraform-chlorotrimethylsilane system and the replacement of the trimethylsiloxy group by halogen and of halogen by halogen by the action of halotrimethylsilanes or acetyl bromide.The reactions of N-(chloromethyl)lactams with carboxylic anhydrides lead to N-(acyloxymethyl)lactams.
Manufacture of haloalkyl lactams
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, (2008/06/13)
A process for the manufacture of haloalkyl lactams having the formula STR1 wherein n is an integer having a value of from 1 to 3; m is an integer having a value of 1 or 2 and X is chlorine or bromine in the absence of an inert solvent by reacting a hydroxyalkyl lactam of the formula STR2 with a thionyl chloride or bromide in the liquid phase under anhydrous conditions, vaporizing and removing any excess thionyl halide along with SO2 by-product from the liquid reaction mixture under vacuum followed by vacuum distillation of the remaining liquid product mixture at a temperature below its decomposition and recovering said product. The product of this process can be obtained in greater than 90% yield and 99% purity.
