68117-63-5Relevant academic research and scientific papers
Ketone Synthesis from Acid Chloride by Means of Organometallic Reagent Derived from R3Al-Cu(acac)2-PPh3 System
Takai, Kazuhiko,Oshima, Koichiro,Nozaki, Hitosi
, p. 1281 - 1282 (1981)
Reaction of acid chlorides or thiocarboxylic S-esters with the title reagent in tetrahydrofuran provides ketones in good to excellent yields.The coupling reactions with allylic halides to form alkene derivatives are also disclosed.
Beta-lactones as antibacterial agents
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Page/Page column 37-38, (2017/01/05)
The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negativ
Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP
Zeiler, Evelyn,Korotkov, Vadim S.,Lorenz-Baath, Katrin,B?ttcher, Thomas,Sieber, Stephan A.
experimental part, p. 583 - 591 (2012/03/26)
Here, we report the synthesis and in depth characterization of a second generation β-lactone derived virulence inhibitors. Based on initial results that emphasized the intriguing possibility to disarm bacteria in their virulence the present study develops
β-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes
Boettcher, Thomas,Sieber, Stephan A.
supporting information; experimental part, p. 4600 - 4603 (2009/02/08)
(Chemical Equation Presented) A chemical proteomic strategy has been applied directly to bacterial proteomes, and b-lactones have been identified as important natural product derivatives with a high affinity to various enzyme classes (see picture). This a
NEW SYNTHETIC 'TRICKS'. ADVANTAGES OF USING TRIETHYLPHOSPHINE IN SOME PHOSPHORUS-BASED REACTIONS
Urpi, Felix,Vilarrasa, Jaume
, p. 4623 - 4624 (2007/10/02)
It is shown that Et3P can advantageously replace Ph3P, Bu3P, and other P(III) reagents in phosphazene reactions (amide and phthalimide formation) and disulphide-cleavage-based reactions (reduction of disulphides, thioester formation, and oxime hydrolysis).
