68119-98-2Relevant academic research and scientific papers
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70
Vu, Chi B.,Corpuz, Evelyn G.,Merry, Taylor J.,Pradeepan, Selvaluxmi G.,Bartlett, Catherine,Bohacek, Regine S.,Botfield, Martyn C.,Eyermann, Charles J.,Lynch, Berkley A.,MacNeil, Ian A.,Ram, Mary K.,Van Schravendijk, Marie Rose,Violette, Shelia,Sawyer, Tomi K.
, p. 4088 - 4098 (2007/10/03)
A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200- 400-fold more potent than the native,
Soluble Substituted μ-Oxo(phthalocyaninato)iron(III) Dimers
Dieing, Reinhold,Schmid, Gabriele,Witke, Elisabeth,Feucht, Carola,Dressen, Michael,et al.
, p. 589 - 598 (2007/10/02)
Attempts to prepare various peripheral tetra- and octasubstituted (phthalocyaninato)iron derivatives RnPcFe by starting from the corresponding substituted phthalonitriles led to substituted (μ-oxo)bis compounds 2O.The tert-butyl- and ethyl-substituted systems 2O (6c) and 2O (6d) were reinvestigated.UV/Vis, FD mass, Moessbauer, NMR as well as ESR spectroscopy was used to characterize the complexes 2O to furnish evidence for the presence of Fe-O-Fe moieties in 2O.The UV/Vis data reported for 2O as well as their spectral behavior in pyridine correspond to unsubstituted 2O.Moessbauer spectra of 2O show that the complexes were obatined as a mixtures of two isomeric μ-oxo compounds A (δFe = 0.22 mm s-1, ΔEQ = 1.33-1.39 mm s-1) and B (δFe = 0.33-0.36 mm s-1, ΔEQ = 0.39-0.53 mm s-1), whose Moessbauer parameters are comparable to 2O μ-oxo(2) and μ-oxo(1), respectively.Moessbauer spectral data of 2O indicate high-spin (S = 5/2) FeIII centers.NMR-spectra of 2O (n = 4: R = tBu, Et, O(2-Et-n-C6H13), OCH2C(CH3)2CH2Ph; n = 8: R = O-n-C8H17, O(2-Et-n-C6H13) give further evidence for μ-oxo bridge structures. - Key Words: μ-Oxobis(phthalocyaninato)iron/ μ-Oxo dimers/ Moessbauer spectroscopy/ Iron complexes/ Phthalocyanines
