681258-68-4Relevant academic research and scientific papers
Metal-Free Synthesis of Pyrrolo[1,2- a ]quinoxalines Mediated by TEMPO Oxoammonium Salts
Huo, Heng-Rui,Tang, Xiang-Ying,Gong, Yue-Fa
, p. 2727 - 2740 (2018/06/20)
We herein describe a novel TEMPO oxoammonium salt initiated Pictet-Spengler reaction of imines, generated in situ from carbonyl compounds and pyrrole- or indole-containing substrates, to afford 4,5-dihydropyrrolo[1,2- a ]quinoxalines or 5,6-dihydroindolo[1,2- a ]quina-oxalines in good to excellent yields. Moreover, a one-pot synthesis of a biologically important quinoxaline is achieved via a cyclization-dehydrogenation process using one equivalent of the oxoammonium salt.
Highly selective synthesis of mono- and bis-4,5-dihydropyrrolo[1,2-a]quinoxalines catalyzed by sustainable supported acidic ionic liquid in water media
Rashidi, Raziyeh,Nasr-Esfahani, Mahboobeh,Mohammadpoor-Baltork, Iraj,Tangestaninejad, Shahram,Moghadam, Majid,Mirkhani, Valiollah
, p. 557 - 567 (2018/03/27)
Abstract: Preparation of substituted as well as the selective synthesis of mono- and bis-4,5-dihydropyrrolo[1,2-a]quinoxalines using a highly efficient, sustainable, and reusable supported acidic ionic liquid is reported. The reaction method is ecofriendl
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists
Szabo, Gyoergy,Kiss, Robert,Payer-Lengyel, Dora,Vukics, Krisztina,Szikra, Judit,Baki, Andrea,Molnar, Laszlo,Fischer, Janos,Keseru, Gyoergy M.
scheme or table, p. 3471 - 3475 (2010/02/28)
Hit-to-lead optimization of a novel series of N-alkyl-N-[2-oxo-2-(4-aryl-4H-pyrrolo[1,2-a]quinoxaline-5-yl)-ethyl]-car boxylic acid amides, derived from a high throughput screening (HTS) hit, are described. Subsequent optimization led to identification of
