1360546-72-0

Basic information

• Product Name: 4-(4-chlorophenyl)pyrrolo[1,2-a]quinoxaline
• Synonyms: 4-(4-chlorophenyl)pyrrolo[1,2-a]quinoxaline
• CAS NO: 1360546-72-0
• Molecular Weight: 278.741
• Mol File: 1360546-72-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorophenyl)pyrrolo[1,2-a]quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)pyrrolo[1,2-a]quinoxaline(1360546-72-0)
• EPA Substance Registry System: 4-(4-chlorophenyl)pyrrolo[1,2-a]quinoxaline(1360546-72-0)

Safety Data

• Hazardous Substances Data: 1360546-72-0(Hazardous Substances Data)

Upstream product

• 33265-60-0 1-(2-nitrophenyl)-1H-pyrrole 
• 37580-81-7 1,2-bis(4-chlorophenyl)-1,2-ethandiol 
• 6025-60-1 2-(1H-pyrrol-1-yl)aniline 
• 99-91-2 para-chloroacetophenone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 106-43-4 para-chlorotoluene 
• 104-88-1 4-chlorobenzaldehyde 
• 104-86-9 4-chlorobenzylamine 
• 74-11-3 para-chlorobenzoic acid 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 681258-68-4 4-(4-chlorophenyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline 
• 122-01-0 4-chloro-benzoyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 350829-07-1 1-[2-isocyanophenyl]-1H-pyrrole 

Relevant articles and documents

Acetic acid catalysed one-pot synthesis of pyrrolo[1,2-a ]quinoxaline derivatives

An efficient acetic acid catalysed reaction has been developed for the synthesis of 4-Aryl substituted pyrrolo[1,2-a ]quinoxalines from readily available starting materials. A range of structures have been synthesised in very good to excellent yields. The one-pot reaction proceeds through imine formation, cyclisation followed by air oxidation.

Synthesis of 4-Aryl Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Oxidative Coupling from an Unactivated Methyl Arene

Herein, we describe the direct synthesis of pyrrolo[1,2-α]quinoxaline via oxidative coupling between methyl arene and 1-(2-aminophenyl) pyrroles. Oxidation of the benzylic carbon of the methyl arene was achieved by di-t-butyl peroxide in the presence of an iron catalyst, followed by conversion to an activated aldehyde in situ. Oxygen played a crucial role in the oxidation process to accelerate benzaldehyde formation. Subsequent Pictet-Spengler-type annulation completed the quinoxaline structure. The protocol tolerated various kinds of functional groups and provided 22 4-aryl pyrrolo[1,2-α]quinoxalines when various methyl arene derivatives were used. The developed method proceeded in air, and all catalysts, reagents, and solvents were easily accessible.

Tin(ii) chloride dihydrate/choline chloride deep eutectic solvent: Redox properties in the fast synthesis of: N -arylacetamides and indolo(pyrrolo)[1,2- a] quinoxalines

In this contribution a physicochemical, IR and Raman characterization for the tin(ii) chloride dihydrate/choline chloride eutectic mixture is reported. The redox properties of this solvent were also studied by cyclic voltammetry finding that it can be successfully used as an electrochemical solvent for electrosynthesis and electroanalytical processes and does not require negative potentials as verified by the reduction of nitrobenzene. The potential use of this eutectic mixture as a redox solvent was further explored in obtaining aromatic amines and N-arylacetamides starting from a wide variety of nitroaromatic compounds. In addition, a fast synthetic strategy for the construction of a series of indolo(pyrrolo)[1,2-a]quinoxalines was developed by reacting 1-(2-nitrophenyl)-1H-indole(pyrrole) with aldehydes. This simple protocol offers a straightforward method for the construction of the target quinoxalines in short reaction times and high yields where the key step involves a tandem one-pot reductive cyclization-oxidation.