681261-26-7

Basic information

• Product Name: 1,N⁵-diphenyl-1H-[1,2,4]triazole-3,5-diyldiamine
• CAS NO: 681261-26-7
• Molecular Weight: 251.291
• Mol File: 681261-26-7.mol

Chemical Properties

• CAS DataBase Reference: 1,N⁵-diphenyl-1H-[1,2,4]triazole-3,5-diyldiamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,N⁵-diphenyl-1H-[1,2,4]triazole-3,5-diyldiamine(681261-26-7)
• EPA Substance Registry System: 1,N⁵-diphenyl-1H-[1,2,4]triazole-3,5-diyldiamine(681261-26-7)

Safety Data

• Hazardous Substances Data: 681261-26-7(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 19981-17-0 sodium cyanamide 
• 103-72-0 phenyl isothiocyanate 
• 92555-53-8 S-benzyl-N-cyano-N'-phenyl-isothiourea 

Relevant articles and documents

A novel one-pot synthesis of 1,2,4-triazole-3,5-diamine derivatives from isothiocyanates and mono-substituted hydrazines

1,2,4-Triazole-3,5-diamine derivatives were synthesized in moderate to high yields in one-pot reaction from the corresponding isothiocyanates, mono-substituted hydrazines, and sodium hydrogencyanamide, in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. Typically, two target compounds were obtained, but high regioselectivities to one isomer were observed when aromatic and sterically bulky hydrazines were used. A number of examples with a detailed representative procedure are given.

Process for the preparation of tri-nitrogen containing heteroaryl-diamine derivatives useful as pharmaceutical agents and methods of producing pharmaceutical agents

This invention provides a process for producing at least one tri-nitrogen containing heteroaryl-diamine derivatives, which are useful as pharmaceutical agents and components, particularly as IMPDH inhibitors, comprising reacting an isothiocyanate with a h