681283-30-7

Upstream product

• 681283-26-1 (5S,3S)-N-benzyloxycarbonyl-5-tert-butyldimethylsilyloxymethyl-3-difluoromethyl-2-pyrrolidone 
• 681283-18-1 methyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate 
• 681283-20-5 methyl (2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylpyroglutamate 
• 51-35-4 4R-4-hydroxyproline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 102195-80-2 (S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 108-24-7 acetic anhydride 
• 681283-28-3 benzyl (2R,3S,5S)-5-tert-butyldimethylsilyloxymethyl-3-difluoromethyl-2-hydroxypyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of 2′,3′-Dideoxy-2′-difluoromethyl Azanucleosides

Methyl (2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylpyroglutamate (9a) was synthesized from trans-4-hydroxy-L-proline (5). Compound 9a was converted to (5S,3S)-N-benzyloxycarbonyl-5-(tert-butyldimethylsilyloxymethyl-3- difluoromethyl-2-pyrrolidone (15) o