6814-68-2

Usage

Uses

Used in Pharmaceutical Research:
1H-Indazole-3-ethanamine is used as a research chemical for studying the effects of synthetic cannabinoids on the CB1 receptor. Its potent agonist activity allows scientists to investigate the mechanisms of action and potential therapeutic applications of cannabinoids in various medical conditions.
Used in Forensic Toxicology:
Due to its association with drug overdoses and fatalities, 1H-Indazole-3-ethanamine is used as a target analyte in forensic toxicology for the detection and analysis of synthetic cannabinoid abuse. Its chemical structure, which is similar to other synthetic cannabinoids, makes it challenging to detect and regulate, necessitating the development of advanced analytical methods for its identification in biological samples.

InChI:InChI=1/C9H11N3/c10-6-5-9-7-3-1-2-4-8(7)11-12-9/h1-4H,5-6,10H2,(H,11,12)

Upstream product

• 100373-98-6 N-[2-(1-acetyl-1H-indazol-3-yl)-ethyl]-acetamide 
• 290368-16-0 [2-(1H-indazol-3-yl)-ethyl]-carbamic acid butyl ester 
• 271-44-3 benzimidazole 
• 66607-27-0 3-iodoindazole 
• 214541-51-2 3-(1H-indazol-3-yl) propanoic acid 
• 290368-11-5 methyl 3-(1H-indazol-3-yl)propanoate 
• 290368-09-1 3-(indazol-3-yl)-propenoic acid methyl ester 
• 290368-00-2 tert-butyl 3-iodo-1H-indazole-1-carboxylate 
• 290368-05-7 tert-butyl 3-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1H-indazole-1-carboxylate 
• 290368-14-8 3-(2-azidocarbonyl-ethyl)-indazole-1-carboxylic acid ethyl ester 
• 290368-15-9 3-(2-butoxycarbonylamino-ethyl)-indazole-1-carboxylic acid ethyl ester 
• 100451-04-5 N-[2-(1-acetyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-ethyl]-acetamide 
• 117882-35-6 3-chloromethyl-1⁽²⁾H-indazole; hydrochloride 
• 807287-45-2 3-chloromethyl-4,5,6,7-tetrahydro-1⁽²⁾H-indazole 

Relevant academic research and scientific papers

Heck cross-couplingg reaction of 3-iodoindazoles with methyl acrylate: A mild and flexible strategy to design 2-azatryptamines

In order to design 2-azabioisosteres of tryptamine, serotonin or melatonin, the conditions of the Heck coupling reaction of 3-iodoindazoles with methyl acrylate are studied. This reaction authorizes the synthesis of 3-indazolylpropenoates as key intermediates to prepare 3-indazolylpropionic acids and 3-indazolylethylamines. The flexible synthetic strategy allows molecular diversity. (C) 2000 Elsevier Science Ltd.