214541-51-2

Basic information

• Product Name: 4-(1H-INDAZOL-3-YL)BUTAN-2-ONE
• Synonyms: 4-(1H-INDAZOL-3-YL)BUTAN-2-ONE
• CAS NO: 214541-51-2
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 214541-51-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 367.2°C at 760 mmHg
• Flash Point: 179.5°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 4-(1H-INDAZOL-3-YL)BUTAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-INDAZOL-3-YL)BUTAN-2-ONE(214541-51-2)
• EPA Substance Registry System: 4-(1H-INDAZOL-3-YL)BUTAN-2-ONE(214541-51-2)

Safety Data

• Hazardous Substances Data: 214541-51-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12N2O/c1-8(14)6-7-11-9-4-2-3-5-10(9)12-13-11/h2-5H,6-7H2,1H3,(H,12,13)

Upstream product

• 1453484-25-7 tert-butyl 3-(3-ethoxy-3-oxopropyl)-1H-indazole-1-carboxylate 
• 290368-05-7 tert-butyl 3-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1H-indazole-1-carboxylate 
• 290368-00-2 tert-butyl 3-iodo-1H-indazole-1-carboxylate 
• 290368-09-1 3-(indazol-3-yl)-propenoic acid methyl ester 
• 66607-27-0 3-iodoindazole 
• 271-44-3 benzimidazole 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 290368-11-5 methyl 3-(1H-indazol-3-yl)propanoate 
• 67767-10-6 3-(3-indazolyl)acrylic acid 

Downstream Products

• 1246519-10-7 C₂₀H₂₃N₅O₃ 
• 1246519-36-7 C₂₀H₂₃N₅O₃ 
• 1246519-08-3 C₁₈H₁₉N₃O₂ 
• 1246518-86-4 C₁₉H₂₁N₃O₃ 
• 1246519-09-4 C₁₇H₁₇N₃O 
• 6814-68-2 2-(1H-indazol-3-yl)ethanamine 

Relevant articles and documents

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

PPAR active compounds

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

Heck cross-couplingg reaction of 3-iodoindazoles with methyl acrylate: A mild and flexible strategy to design 2-azatryptamines

In order to design 2-azabioisosteres of tryptamine, serotonin or melatonin, the conditions of the Heck coupling reaction of 3-iodoindazoles with methyl acrylate are studied. This reaction authorizes the synthesis of 3-indazolylpropenoates as key intermediates to prepare 3-indazolylpropionic acids and 3-indazolylethylamines. The flexible synthetic strategy allows molecular diversity. (C) 2000 Elsevier Science Ltd.