681424-33-9

Upstream product

• 681424-92-0 (S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid pentafluorophenyl ester 
• 622-33-3 N-benzyloxyamine 
• 681424-86-2 (S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has become an

ANTIMICROBIAL [3.1.0] BICYCLIC OXAZOLIDINONE DERIVATIVES

The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them,