68144-27-4Relevant academic research and scientific papers
A tractable and efficient one-pot synthesis of 5′-azido-5′- deoxyribonucleosides
Peterson, Theodore V.,Streamland, Tobin U. B.,Awad, Ahmed M.
, p. 2434 - 2444 (2014)
Synthetic routes to 5′-azidoribonucleosides are reported for adenosine, cytidine, guanosine, and uridine, resulting in a widely applicable one-pot methodology for the synthesis of these and related compounds. The target compounds are appropriate as precursors in a variety of purposive syntheses, as the synthetic and therapeutic relevance of azido- and amino-modified nucleosides is expansive. Furthermore, in the conversion of alcohols to azides, these methods offer a tractable alternative to the Mitsunobu and other more difficult reactions.
