68144-26-3

Basic information

• Product Name: 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine
• Synonyms: 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine
• CAS NO: 68144-26-3
• Molecular Weight: 436.43
• Mol File: 68144-26-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine(68144-26-3)
• EPA Substance Registry System: 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine(68144-26-3)

Safety Data

• Hazardous Substances Data: 68144-26-3(Hazardous Substances Data)

Upstream product

• 40982-79-4 N⁶,N⁶-dibenzoyl-5'-O-mesyl-2',3'-O-isopropylidene adenosine 
• 39947-05-2 ((3aR,4R,6R,6aR)-6-(6-benzamido-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate 
• 1348775-39-2 adenosine 
• 98-88-4 benzoyl chloride 
• 68144-27-4 N⁶-benzoyl-5'-bromo-O^2'_,O3'-isopropylidene-5'-deoxy-adenosine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 68179-90-8 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl methanesulfonate 
• 77-76-9 2,2-dimethoxy-propane 
• 4546-55-8 N-benzoyladenosine 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 40653-96-1 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine 

Downstream Products

• 1229845-80-0 5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneuridine-6-methyl-(6(1)->5'-N)-5'-amino-N6-benzoyl-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 1229845-69-5 5'-acetamido-5'-deoxy-N₆-benzoyl-2',3'-O-isopropylideneadenosine 
• 162757-18-8 1-(5'-deoxy-N⁶,N⁶-dibenzoyl-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonyl-isothiourea 
• 162757-19-9 1-(N⁶-benzoyl-5'-deoxy-adenosin-5'-yl)-2-methyl-3-phenylsulfonyl-isothiourea 
• 162757-20-2 5'-amino-5'-deoxy-N⁶-benzoyl-3'-O,5'-N-(N-phenylsulfonyliminocarbonyl)adenosine 
• 162757-17-7 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea 
• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 213554-36-0 C₂₇H₃₆N₈O₉S 
• 256643-15-9 5'-aminosulfamoyl-5'-deoxy-2',3'-O-isopropylidene-N⁶-benzoyladenosine 
• 737-76-8 5'-azido-5'-deoxyadenosine 
• 14365-44-7 5'-amino-5'-deoxyadenosine 
• 949572-36-5 C₂₃H₂₄N₇O₆Cl 
• 57610-04-5 N⁶-benzoyl-5'-azidoadenosine 
• 256643-14-8 5'-amino-5'-deoxy-2',3'-O-isopropylidene-N⁶-benzoyladenosine 

Relevant articles and documents

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Oligonucleotide analogues with integrated bases and backbones. Part 24: Synthesis, conformational analysis, and association of aminomethylene-linked self-complementary adenosine and uridine dinucleosides

Inspection of Maruzen models and force-field calculations suggest that oligonucleotide analogues integrating backbone and bases (ONIBs) with an aminomethylene linker form similar cyclic duplexes as the analogous oxymethylene linked dinucleosides. The self

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases

Molecular modelling and synthetic studies have been carried out on tyrosinyl adenylate and analogues to probe the interactions seen in the active site of the X-ray crystal structure of tyrosyl tRNA synthetase from Bacillus stearothermophilus, and to search for new inhibitors of this enzyme. Micromolar and sub-micromolar inhibitors of tyrosyl tRNA synthetases from both B. stearothermophilus and Staphylococcus aureus have been synthesised. The importance of the adenine ring to the binding of tyrosinyl adenylate to the enzyme, and the importance of water-mediated hydrogen bonding interactions, have been highlighted. The inhibition data has been further supported by homology modelling with the S. aureus enzyme, and by ligand docking studies. (C) 1999 Elsevier Science Ltd.