68145-31-3

Basic information

• Product Name: methyl 3-methoxy-2-phenylpropanoate
• Synonyms: methyl 3-methoxy-2-phenylpropanoate
• CAS NO: 68145-31-3
• Molecular Weight: 194.23
• Mol File: 68145-31-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-methoxy-2-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-methoxy-2-phenylpropanoate(68145-31-3)
• EPA Substance Registry System: methyl 3-methoxy-2-phenylpropanoate(68145-31-3)

Safety Data

• Hazardous Substances Data: 68145-31-3(Hazardous Substances Data)

Upstream product

• 40195-27-5 (1-methoxy-2-phenylvinyloxy)trimethylsilane 
• 107-30-2 chloromethyl methyl ether 
• 3967-53-1 methyl tropate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Kinetic resolution of racemic α-arylalkanoic acids with achiral alcohols via the asymmetric esterification using carboxylic anhydrides and acyl-transfer catalysts

A variety of optically active carboxylic esters are produced by the kinetic resolution of racemic α-substituted carboxylic acids using achiral alcohols, aromatic or aliphatic carboxylic anhydrides, and chiral acyl-transfer catalysts. The combination of 4-methoxybenzoic anhydride (PMBA) or pivalic anhydride with the modified benzotetramisole-type catalyst ((S)-β-Np-BTM) is the most effective for promotion of the enantioselective coupling reaction between racemic carboxylic acids and a novel nucleophile, bis(α-naphthyl) methanol, to give the corresponding esters with high ees. This protocol was successfully applied to the production of nonracemic nonsteroidal anti-inflammatory drugs from racemic compounds utilizing the transacylation process to generate the mixed anhydrides from the acid components with the suitable carboxylic anhydrides.