681463-77-4

Basic information

• Product Name: 1,3-bis-(2-benzoylamino-ethyl)-benzene
• CAS NO: 681463-77-4
• Molecular Weight: 372.467
• Mol File: 681463-77-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis-(2-benzoylamino-ethyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis-(2-benzoylamino-ethyl)-benzene(681463-77-4)
• EPA Substance Registry System: 1,3-bis-(2-benzoylamino-ethyl)-benzene(681463-77-4)

Safety Data

• Hazardous Substances Data: 681463-77-4(Hazardous Substances Data)

Upstream product

• 4289-36-5 1,3-Bis(2-aminoethyl)benzol 
• 98-88-4 benzoyl chloride 
• 108-57-6 1,3-divinylbenzene 
• 55-21-0 benzamide 

Downstream Products

• 412034-36-7 N-[2-(1-phenyl-3,4-dihydro-[6]isoquinolyl)-ethyl]-benzamide 

Relevant articles and documents

Base-Mediated Anti-Markovnikov Hydroamidation of Vinyl Arenes with Arylamides

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.