681481-89-0Relevant articles and documents
TSPO PIGA ligands promote neurosteroidogenesis and human astrocytewell-being
da Pozzo, Eleonora,Giacomelli, Chiara,Costa, Barbara,Cavallini, Chiara,Taliani, Sabrina,Barresi, Elisabetta,Da Settimo, Federico,Martini, Claudia
, (2016)
The steroidogenic 18 kDa translocator protein (TSPO) is an emerging, attractive therapeutic tool for several pathological conditions of the nervous system. Here, 13 high affinity TSPO ligands belonging to our previously described N,N-dialkyl-2-phenylindol
N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Renzodiazepine Receptor
Primofiore, Giampaolo,Da Settimo, Federico,Taliani, Sabrina,Simorini, Francesca,Patrizi, Maria Paola,Novellino, Ettore,Greco, Giovanni,Abignente, Enrico,Costa, Barbara,Chelli, Beatrice,Martini, Claudia
, p. 1852 - 1855 (2007/10/03)
We report the synthesis and the affinity data at both the peripheral (PBR) and the central benzodiazepine receptors of a series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide derivatives III, designed as conformationally constrained analogues of 2-phenylin