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(R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole, also known as (2R)-3-(2-chloro-4-nitro-1H-imidazol-1-yl)-2-methyl-1,2-propanediol, is an organic compound that serves as an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication.

681490-91-5

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681490-91-5 Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole is used as an intermediate in the synthesis of Delamanid (D230660) for its potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis. It plays a crucial role in the development of new anti-tuberculosis medications by inhibiting mycolic acid synthesis, which is essential for the survival and growth of Mycobacterium tuberculosis.

Check Digit Verification of cas no

The CAS Registry Mumber 681490-91-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,1,4,9 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 681490-91:
(8*6)+(7*8)+(6*1)+(5*4)+(4*9)+(3*0)+(2*9)+(1*1)=185
185 % 10 = 5
So 681490-91-5 is a valid CAS Registry Number.

681490-91-5Relevant academic research and scientific papers

SUBSTITUTED 1,2,3-TRIAZOL-1-YL-METHYL-2,3-DIHYDRO-2-METHYL-6-NITROIMIDAZO[2,1-B]OXAZOLES AS ANTI-MYCOBACTERIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF

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Page/Page column 11; 13, (2016/05/24)

The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their method of preparation and their use as drugs for treatment of tuberculosis, MDR-TB and XDR-TB either

Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: In vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation

Munagala, Gurunadham,Yempalla, Kushalava Reddy,Singh, Samsher,Sharma, Sumit,Kalia, Nitin Pal,Rajput, Vikrant Singh,Kumar, Sunil,Sawant, Sanghapal D.,Khan, Inshad Ali,Vishwakarma, Ram A.,Singh, Parvinder Pal

supporting information, p. 3610 - 3624 (2015/03/30)

The nitroimidazole scaffold has attracted great interest in the last decade, which ultimately led to the discovery of the successful drug Delamanid for multi-drug resistant tuberculosis (MDR-TB). Herein, we report medicinal chemistry on a 6-nitro-2,3-dihy

6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF

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Sheet 3, (2015/04/22)

The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2, 3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for

Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles

Sasaki, Hirofumi,Haraguchi, Yoshikazu,Itotani, Motohiro,Kuroda, Hideaki,Hashizume, Hiroyuki,Tomishige, Tatsuo,Kawasaki, Masanori,Matsumoto, Makoto,Komatsu, Makoto,Tsubouchi, Hidetsugu

, p. 7854 - 7860 (2007/10/03)

In an effort to develop potent new antituberculosis agents that would be effective against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis, we prepared a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxaz

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