681510-01-0

Basic information

• Product Name: 2-METHOXY-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 2-METHOXY-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• CAS NO: 681510-01-0
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.6
• Mol File: 681510-01-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(681510-01-0)
• EPA Substance Registry System: 2-METHOXY-6-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(681510-01-0)

Safety Data

• Hazardous Substances Data: 681510-01-0(Hazardous Substances Data)

Upstream product

• 119692-41-0 2-methoxy-6-(trifluoromethyl)benzoic acid 

Downstream Products

• 1558680-91-3 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-trifluoromethyl-benzamide 
• 654683-21-3 C₁₁H₁₂F₃NO₂ 

Relevant articles and documents

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-DI-SUBSTITUTED CYCLOBUTENE-1, 2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (I)or a pharmaceutically acceptable salt or solvate thereof. Also disclosed is the treatment of chemokine-mediated diseases using compounds of the formula (II)