1558680-91-3Relevant academic research and scientific papers
3-amido-3-aryl-piperidines: A novel class of potent, selective, and orally active GlyT1 inhibitors
Pinard, Emmanuel,Alberati, Daniela,Alvarez-Sanchez, Ruben,Brom, Virginie,Burner, Serge,Fischer, Holger,Hauser, Nicole,Kolczewski, Sabine,Lengyel, Judith,Mory, Roland,Saladin, Christian,Schulz-Gasch, Tanja,Stalder, Henri
, p. 428 - 433 (2014/05/06)
3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.
