68152-40-9Relevant academic research and scientific papers
Photoinduced C(sp3)-H sulfination empowers the direct and chemoselective introduction of the sulfonyl group
Arman, Hadi D.,Haug, Graham C.,Jin, Shengfei,Larionov, Oleg V.,Nguyen, Viet D.,Trevino, Ramon
, p. 13914 - 13921 (2021/11/04)
Direct installation of the sulfinate group by the functionalization of unreactive aliphatic C-H bonds can provide access to most classes of organosulfur compounds, because of the central position of sulfinates as sulfonyl group linchpins. Despite the importance of the sulfonyl group in synthesis, medicine, and materials science, a direct C(sp3)-H sulfination reaction that can convert abundant aliphatic C-H bonds to sulfinates has remained elusive, due to the reactivity of sulfinates that are incompatible with typical oxidation-driven C-H functionalization approaches. We report herein a photoinduced C(sp3)-H sulfination reaction that is mediated by sodium metabisulfite and enables access to a variety of sulfinates. The reaction proceeds with high chemoselectivity and moderate to good regioselectivity, affording only monosulfination products and can be used for a solvent-controlled regiodivergent distal C(sp3)-H functionalization.
Substituted inmidazoles as bombesin receptor subtype-3 modulators
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Page/Page column 83, (2010/02/17)
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.
Mechanism of Sodium Dithionite Reduction of Aldehydes and Ketones
Chung, Sung-Kee
, p. 5457 - 5458 (2007/10/02)
A reduction mechanism involving an α-hydroxy sulfinate intermediate has been suggested for the title reaction, on the basis of a radical ring-opening probe and the source of the hydrogen.
