68161-60-4

Basic information

• Product Name: 5-(4-ETHOXY-PHENYLAMINO)-[1,3,4]THIADIAZOLE-2-THIOL
• Synonyms: 5-(4-ethoxyanilino)-3H-1,3,4-thiadiazole-2-thione
• CAS NO: 68161-60-4
• Molecular Formula: C₁₀H₁₁N₃OS₂
• Molecular Weight: 253.3438
• Mol File: 68161-60-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 371°Cat760mmHg
• Flash Point: 178.2°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: 5-(4-ETHOXY-PHENYLAMINO)-[1,3,4]THIADIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-ETHOXY-PHENYLAMINO)-[1,3,4]THIADIAZOLE-2-THIOL(68161-60-4)
• EPA Substance Registry System: 5-(4-ETHOXY-PHENYLAMINO)-[1,3,4]THIADIAZOLE-2-THIOL(68161-60-4)

Safety Data

• Hazardous Substances Data: 68161-60-4(Hazardous Substances Data)

Usage

Chemical structure

Thiadiazole derivative consisting of a thiophene ring fused to a 1,3,4-thiadiazole ring

Pharmacological activities

Potential pharmacological activities

Applications

Can be used in the development of pharmaceutical drugs, important in organic synthesis and medicinal chemistry

InChI:InChI=1/C10H11N3OS2/c1-2-14-8-5-3-7(4-6-8)11-9-12-13-10(15)16-9/h3-6H,2H2,1H3,(H,11,12)(H,13,15)

Upstream product

• 125908-43-2 1-butyl-6-(4'-ethoxyphenyl)-2,5-dithiobiurea 
• 125908-42-1 1-propyl-6-(4'-ethoxyphenyl)-2,5-dithiobiurea 
• 125908-34-1 1-ethyl-6-(4'-ethoxyphenyl)-2,5-dithiobiurea 
• 125908-30-7 1-methyl-6-(4'-ethoxyphenyl)-2,5-dithiobiurea 
• 75-15-0 carbon disulfide 
• 64374-52-3 4-(p-ethoxyphenyl)thiosemicarbazide 

Downstream Products

• 68161-44-4 [5-(4-ethoxy-anilino)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid 
• 73311-06-5 (4-ethoxy-phenyl)-(5-ethylsulfanyl-[1,3,4]thiadiazol-2-yl)-amine 

Relevant articles and documents

Synthesis and antifungal activities of ω-(5-arylamino-1,3,4-thiadiazol-2-thio)-ω(1H-1,2,4-triazol-1-yl) acetophenones

Several ω-(5-arylamino-1,3,4-thiadiazol-2-thiol)-ω-(1H-1,2,4-triazol-1- yl)acetophenones 4a-i have been synthesized. The representative compounds exhibit some antifungal and plant growth regulatory activities. The structures of these compounds have been confirmed by elemental analyses, 1H NMR, IR and MS spectra.

Alkali catalyzed thermal cyclization of 1-substituted and 1,6-disubstituted 2,5-dithiobiureas: Formation of 1,2,4-triazolidine-3,5-dithiones and/or 1,3,4-thiadiazoline-5-thiones

Alkali catalyzed thermal cyclization of 1-alkyl and 1,6-dialkyl-2,5-dithiobiureas (I, R=alkyl, R'=H and R=R'=alkyl) results in the formation of 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) (alkyl=Me or Et) and 2-alkylamino-Δ2-1,3,4-thiadiazoline-5-thiones (VI) (alkyl=n-Pr or n-Bu).Under the same conditions, 1-alkyl-6-aryl-2,5-dithiobiureas (I, R=alkyl, R'=aryl) give 2-arylamino-Δ2-1,3,4-thiadiazoline-5-thiones (IX) (alkyl=Me, Et, n-Pr or n-Bu) and 4-alkyl-1,2,4-triazolidine-3,5-dithiones (V) also when the alkyl groups are Me or Et.