68168-94-5

Basic information

• Product Name: (2R,3S)-methyl 2-acetamido-3-hydroxybutanoate
• Synonyms: (2R,3S)-methyl 2-acetamido-3-hydroxybutanoate
• CAS NO: 68168-94-5
• Molecular Weight: 175.185
• Mol File: 68168-94-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2R,3S)-methyl 2-acetamido-3-hydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-methyl 2-acetamido-3-hydroxybutanoate(68168-94-5)
• EPA Substance Registry System: (2R,3S)-methyl 2-acetamido-3-hydroxybutanoate(68168-94-5)

Safety Data

• Hazardous Substances Data: 68168-94-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 17093-74-2 N-acetyl-DL-theanine 
• 98432-01-0 methyl 2-acetamido-3-oxobutanoate 
• 207348-26-3 (Z)-2-Acetylamino-3-(tert-butyl-dimethyl-silanyloxy)-but-2-enoic acid methyl ester 
• 39994-75-7 threonine methyl ester hydrochloride 
• 186581-53-3 diazomethane 

Relevant articles and documents

ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE

This application discloses a composition comprising a malodor compound and an anti-odor ingredient effective for reducing the presence or production of malodor. The composition may be topically applied to a subject and is useful for cosmetic conditions, pharmaceutical indications, or other objectives.

ASYMMETRIC SYNTHESIS. PRACTICAL PRODUCTION OF D AND L THREONINE. DYNAMIC KINETIC RESOLUTION IN RHODIUM AND RUTHENIUM CATALYZED HYDROGENATION OF 2-ACYLAMINO-3-OXOBUTYRATES.

Enantioselective syntheses of D and L threonine are described.Racemic methyl and ethyl 2-acylamino-3-oxobutyrate 1 were synthesized from the corresponding acetoacetates 6 and then hydrogenated stereoselectively via dynamic kinetic resolution with various chiral P * P Rh(I) 8 and Ru(II) 10 catalysts to give syn optically active alcohols which could be converted by hydrolysis and treatment with propylene oxide into threonine.The best results were obtained using (-) CHIRAPHOS Ru and (+) BINAP Ru as catalysts, in the hydrogenation step leading respectively to D threonine (ee : 99percent) and L threonine (ee : 94percent) in 26-34percent overall yields.

Applications of 1-Alkoxycarbonyl- and 1-Acyl-v-triazolopyridines as Acylating Reagents

Selective N-protection of hydroxyamino esters has been readily achieved using 1-alkoxycarbonyl- or 1-acyl-v-triazolopyridines.The amide-type triazolides reacted with alcohols in the presence of DBU at room temperature to afford in high yields the corresponding esters.The different reactivity of 1- and 3-alkoxycarbonyl derivatives of the title bicyclic system toward primary amines has been further investigated.