6817-41-0

Basic information

• Product Name: Isoliensinine
• Synonyms: Isoliensinine;(+)-Isoliensinin;(1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
• CAS NO: 6817-41-0
• Molecular Formula: C37H42N2O6
• Molecular Weight: 610.747
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 6817-41-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 69-71℃
• Boiling Point: 723.1 °C at 760 mmHg
• Flash Point: 391.1 °C
• Appearance: /
• Density: 1.218
• Vapor Pressure: 1.32E-21mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.28±0.45(Predicted)
• CAS DataBase Reference: Isoliensinine(CAS DataBase Reference)
• NIST Chemistry Reference: Isoliensinine(6817-41-0)
• EPA Substance Registry System: Isoliensinine(6817-41-0)

Safety Data

• Hazardous Substances Data: 6817-41-0(Hazardous Substances Data)

Usage

Description

Isoliensinine is a bisisoquinoline alkaloid derived from the embryo of the seeds of Nelumbo nucifera Gaertn, also known as the sacred lotus. It exhibits unique optical rotation properties and is characterized by the presence of three methoxyl, two hydroxyl, and two methylimino groups. Isoliensinine has been found to activate AMP-activated kinase and regulate PPARγ receptors, making it a potential candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Applications:
Isoliensinine is used as a therapeutic agent for its ability to activate AMP-activated kinase and regulate PPARγ receptors. These properties suggest potential applications in the treatment of metabolic disorders and other conditions related to the dysregulation of these cellular pathways.
Used in Drug Development:
Isoliensinine's unique biochemical properties make it a valuable compound for further research and development in the pharmaceutical industry. Its potential to modulate cellular pathways involved in various diseases positions it as a promising candidate for the development of new drugs targeting these pathways.
Used in Metabolic Research:
The activation of AMP-activated kinase and regulation of PPARγ receptors by Isoliensinine make it a valuable tool in metabolic research. It can be used to study the underlying mechanisms of these pathways and their role in metabolic diseases, potentially leading to the discovery of novel therapeutic targets and treatments.

References

Tomita et aI., Tetrahedron Lett., 2637,3374 (1964)

InChI:InChI=1/C37H42N2O6/c1-38-15-13-26-20-36(44-5)37(22-29(26)30(38)16-23-6-9-27(42-3)10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(43-4)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1