68172-49-6Relevant academic research and scientific papers
Preparation of tetraalkylformamidinium salts and related species as precursors to stable carbenes
Alder, Roger W.,Blake, Michael E.,Bufali, Simone,Butts, Craig P.,Guy Orpen,Schuetz, Jan,Williams, Stuart J.
, p. 1586 - 1593 (2007/10/03)
The preparation of a range of tetraalkylformamidinium salts for use as precursors for the formation of stable diamino-and amino-carbenes was discussed. The preparation methods included nucleophilic addition to formamides followed by trapping with electrophiles such as triflic anhydride and various methods of formamide activation. Exchange reactions involving orthoesters, the transamination of amidinium salts and alkylation methods were other methods suitable for the synthesis.
Inhibition of human alcohol dehydrogenases by formamides
Schindler, John F.,Berst, Kristine B.,Plapp, Bryce V.
, p. 1696 - 1701 (2007/10/03)
Human alcohol dehydrogenase (HsADH) comprises class I (α, β, and γ), class II (π), and class IV (σ) enzymes. Selective inhibitors of the enzymes could be used to prevent the metabolism of alcohols that form toxic products. Formamides are unreactive analog
Process for the preparation of formamides
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, (2008/06/13)
A process for the preparation of formamides by reacting a tertiary amine with carbon monoxide in the presence of a solvent, a catalytic quantity of a copper salt and oxygen or an oxygen-containing gaseous mixture. The reaction is preferably carried out in the presence of excess amine, a volatile alcohol solvent, and a copper halide catalyst.
