68175-73-5Relevant academic research and scientific papers
Phenylhydrazone compound and preparing method, detection method and application thereof
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Paragraph 0048; 0049; 0050; 0051; 0052; 0053-0060, (2017/06/02)
The invention relates to a phenylhydrazone compound and a preparing method, detection method and application thereof. The phenylhydrazone compound is shown as the formula (I), and is a related substance generated in the edaravone synthetic process. The preparing method includes the steps that phenylhydrazine, ethyl acetoacetate and sodium hydrogen sulfite are added into water or an organic solvent, the mixture is reacted, and after the reaction is completed, silica column chromatography separation is carried out, and the phenylhydrazone compound is obtained. The invention also provides a method for measuring the phenylhydrazone compound, edaravone and related substrates thereof with the high-performance liquid chromatography method, the method is easy and convenient to operate, and the measuring result is accurate and reliable. The phenylhydrazone compound can serve as an impurity reference substance to be used for related substance inspection of edaravone raw-material medicine and a preparation thereof, the quality of an edaravone product is controlled, and the safety and the controllability are improved. The formula is defined in the specification.
Preparation of hydrazonates from orthoesters and phenylhydrazine
Br?tulescu, George
, p. 559 - 560 (2008/09/16)
Eight hydrazonates were prepared by an original method in heterogeneous medium on alumina support and microwaves. The irradiation time was between six and nine minutes and the yields were good. The products were characterised by elemental analysis and IR spectroscopy.
