6818-51-5Relevant academic research and scientific papers
Iterative Synthesis of Polydeoxypropionates Based on Iridium-Catalyzed Asymmetric Hydrogenation of α-Substituted Acrylic Acids
Che, Wen,Wen, Danyang C.,Zhu, Shou-Fei,Zhou, Qi-Lin
supporting information, p. 3305 - 3309 (2018/06/11)
A novel iterative protocol for the synthesis of polydeoxypropionates was developed based on iridium-catalyzed asymmetric hydrogenation of α-substituted acrylic acids. The catalyst loading can be as low as 0.01 mol %, and the overall yield for one iterativ
De novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5 H)-one
Kunkalkar, Rupesh A.,Laha, Debasish,Fernandes, Rodney A.
, p. 9072 - 9079 (2016/10/07)
A de novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one has been achieved. Ring-closing-metathesis has been the key step in the synthesis. In (+)-muricadienin synthesis, a long chain alkyl group has been installed by an sp-sp3 Sonogashira type reaction followed by a cis-selective Lindlar reduction. The total synthesis is achieved in 7 steps and in excellent 43.5% overall yield. Similarly, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one synthesis is completed in 5 steps each and in 48 and 68% overall yields, respectively.
Novel Synthesis of α-Substituted Acrylic Acids
Serota, S.,Simon, J. R.,Murray, E. B.,Linfield, W. M.
, p. 4147 - 4151 (2007/10/02)
A facile three-step procedure has been developed for the synthesis of α-substituted acrylic acids.In the first step, a carboxylic acid having no α-substituents is condensed with 2-amino-2-methylpropanol (AMP) to form the corresponding oxazoline.The oxazoline reacts readily with paraformaldehyde to give an intermediate mixture of mono- and dimethylol derivatives which upon heating forms the α-methylene derivatives of the oxazoline.The latter, upon acid hydrolysis, yields the α-substituted acrylic acid generally in an overall yield of above 70percent and the acids are usually at least 95percent pure.
α-Alkyl-substituted glycidates and thioglycidates
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, (2008/06/13)
Glycidates and thioglycidates substituted in the α-position with a long chain alkyl of from 11 to 16 carbons having hypoglycemic activity.
