84515-41-3

Upstream product

• 92822-43-0 ethyl 2-methylene-3-t-butylthiopropanoate 
• 112-67-4 n-hexadecanoyl chloride 
• 3811-73-2 2-mercaptopyridine-1-oxide sodium salt 

Downstream Products

• 6818-51-5 2-Hexadecyl-acrylic acid 
• 84515-59-3 (S)-2-[((R)-2-Ethoxycarbonyl-octadecyl)-ethyl-carbamoyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid benzyl ester 
• 84514-54-5 (S)-2-[((S)-2-Ethoxycarbonyl-octadecyl)-ethyl-carbamoyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

The Invention of New Radical Chain Reactions. Part 12. Improved Methods for the Addition of Carbon Radicals to Substituted Allylic Groups

Reagents for the allylation of carbon radicals derived from the esters (mixed anhydrides) of N-hydroxy-2-thiopyridone have been investigated.Because of competition between the background reaction of decarboxylative rearrangement and the desired allylation process, conventional allylation reagents give moderate yields of the desired adducts.Improved yields are secured if the β-position bears an electron withdrawing group.A concerted addition and elimination process can be postulated.

CARBETHOXYALLYLATION USING RADICAL CHEMISTRY

Radicals derived from the esters of N-hydroxy-2-thiopyridone react smoothly in a concerted reaction with 2-carbethoxy-3-t-butylthioprop-1-ene to give the corresponding 2-carbethoxyallyl derivatives with shift of the double bond.