681807-18-1

Upstream product

• 81477-91-0 benzyl 2-(diphenylmethyleneamino)acetate 
• 79-03-8 propionyl chloride 
• 1140909-08-5 benzyl 2-tert-butoxycarbonylamino-3-oxopentanoate 

Downstream Products

• 1229419-49-1 2-benzoylamino-4-methyl-3-oxo-butanoic acid benzyl ester 
• 1229419-50-4 5-ethyl-2-phenyl-oxazole-4-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Inhibitors of Diacylglycerol Acyltransferase

Provided herein are amides containing at least a four ring structure, which are inhibitors of diacylglycerol acyltransferase and are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Direct anti-selective asymmetric hydrogenation of α-amino-β-keto esters through dynamic kinetic resolution using Ru-axially chiral phosphine catalysts-stereoselective synthesis of anti-β-hydroxy-α-amino acids

The asymmetric hydrogenation of α-amino-β-keto esters using ruthenium (Ru) anti-selectively proceeds via a dynamic kinetic resolution to afford anti-β-hydroxy-α-amino acids with high enantiomeric purities, which are important chiral building blocks for the synthesis of medicines and natural products. A mechanistic investigation has revealed that the Ru-catalyzed asymmetric hydrogenation takes place via the hydrogenation of the double bond in the enol tautomer of the substrate.