68212-26-0

Usage

InChI:InChI=1/C15H12ClN3OS/c16-11-6-8-13(9-7-11)20-10-14-17-18-15(21)19(14)12-4-2-1-3-5-12/h1-9H,10H2,(H,18,21)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 2381-75-1 (4-chlorophenoxy)acetic acid hydrazide 
• 35196-40-8 1-[(4-chloro-phenoxy)-acetyl]-4-phenyl-thiosemicarbazide 
• 14426-42-7 ethyl p-chlorophenoxyacetate 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 129545-11-5 5-(4-Chloro-phenoxymethyl)-2-morpholin-4-ylmethyl-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 129573-99-5 C₃₆H₃₄Cl₂N₈O₂S₂ 
• 129544-90-7 1-[5-(4-Chloro-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-1H-benzotriazole 
• 76659-41-1 O,O-dimethyl-S-<3-(4'-chlorophenoxymethyl)-N⁴-phenyl-1,2,4-triazol-5-yl>dithiophosphate 
• 131142-21-7 (3-p-chlorophenoxymethyl-4-phenyl-1,2,4-triazol-5-yl thio) acetate 
• 131942-87-5 2-[5-(4-Chloro-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-phenyl-acetamide 
• 131943-00-5 2-[5-(4-Chloro-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-(4-p-tolyl-thiazol-2-yl)-acetamide 
• 131942-99-9 2-[5-(4-Chloro-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-(4-phenyl-thiazol-2-yl)-acetamide 
• 76111-31-4 3-(4-Chloro-phenoxymethyl)-5-ethylsulfanyl-4-phenyl-4H-[1,2,4]triazole 
• 129544-88-3 3-(benzylthio)-5-((4-chlorophenoxy)methyl)-4-phenyl-4H-1,2,4-triazole 
• 131943-03-8 (3-p-chlorophenoxymethyl-4-phenyl-1,2,4-triazol-5-yl thio) acetyl hydrazide 
• 129573-97-3 3-(4-Chloro-phenoxymethyl)-5-(3,5-dimethyl-1H-pyrazol-4-ylsulfanyl)-4-phenyl-4H-[1,2,4]triazole 
• 1027982-45-1 β-(3-p-chlorophenoxymethyl-4-phenyl-5-thio-1,2,4-triazol-1-yl)propionamide 
• 131942-89-7 2-[5-(4-Chloro-phenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-(4-methoxy-phenyl)-acetamide 

Relevant academic research and scientific papers

One-pot synthesis and crystal structure of 4-phenyl-3-[4- chlorophenoloxymethyl]-1H-1,2,4-triazole-5(4H)-thione

4-Phenyl-3-[4-chlorophenoloxymethyl]-1H-1,2,4-triazole-5-thione was synthesized with one-pot method. The structure of the title compound was conformed by IR, 1H NMR, elemental analysis studies, and the crystal structure was determined by X-ray diffraction

A 1, 2, 4 - triazole thioether derivative and its preparation and use

The invention discloses a 1,2,4-triazolothio-ether derivative as well as a preparation and an application thereof. The compound with the concentration being 10 mu g/mL has better inhibition property on pythium ultimum trow, and the inhibition rate is up t

USE OF DERIVATIVES OF 2, 4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONE AS INHIBITORS O FTEH ENZYME MYELOPEROXIDASE (MPO)

There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.