682153-68-0Relevant academic research and scientific papers
An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions
Motaleb, Abdul,Bera, Asish,Maity, Pradip
, p. 5081 - 5085 (2018)
A catalyst bound α-aminoalkyl radical intermediate from iminium is developed to control its formation and reactivity with aerobic oxygen. The influence of the catalyst was demonstrated via the ease of radical intermediate formation and its subsequent reactivity, including the first catalyst-controlled enantioselective aerobic oxidation with a chiral phosphite catalyst.
An Enantioselective Access to 1-Alkyl-1,2,3,4-tetrahydroisoquinolines. Application to a New Synthesis of (-)-Argemonine
Youte, Jean-Jacques,Barbier, Denis,Al-Mourabit, Ali,Gnecco, Dino,Marazano, Christian
, p. 2737 - 2740 (2007/10/03)
Potassium ferricyanide oxidation of salt 1 gave isoquinolinone 7 whose treatment with Grignard reagents resulted in a high-yield formation of substituted isoquinolinium salts 5. The selectivity of the reduction of these salts to give derivatives 6 has been studied. Particularly good selectivities (82-84%) were observed when R is a benzylic group. On the basis of these results, a practical and enantioselective synthesis of the natural alkaloid (-)-argemonine is presented.
