68223-02-9

Usage

Uses

Used in Pharmaceutical Production:
CBZ-D-ALANINE METHYL ESTER is used as a chiral building block for the synthesis of pharmaceuticals, playing a crucial role in the creation of peptide-based drugs. Its unique properties allow for the development of compounds with specific therapeutic effects, contributing to the advancement of medicine.
Used in Bioactive Compound Synthesis:
In the synthesis of bioactive compounds, CBZ-D-ALANINE METHYL ESTER serves as a key component. Its incorporation into these molecules can lead to the enhancement of biological activity, making it an essential tool in the discovery and production of new bioactive substances.
Used in Organic Synthesis:
CBZ-D-ALANINE METHYL ESTER is utilized as a reagent in organic synthesis, where it aids in the preparation of a variety of organic molecules. Its versatility in this field allows for the creation of diverse chemical entities with potential applications across different industries.
Used in Medicinal Chemistry:
Within the domain of medicinal chemistry, CBZ-D-ALANINE METHYL ESTER is employed for its potential to contribute to drug discovery. Its involvement in the synthesis of pharmacologically active molecules makes it a valuable resource in the search for new therapeutic agents.
Used in Drug Discovery:
CBZ-D-ALANINE METHYL ESTER plays a significant role in drug discovery, where its properties are harnessed to develop new drugs with improved efficacy and selectivity. Its applications in this area are crucial for the ongoing progress in medicinal research and the development of life-saving treatments.

Upstream product

• 186581-53-3 diazomethane 
• 21691-41-8 (2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid 
• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 74-88-4 methyl iodide 
• 68223-03-0 (R)-2-(((benzyloxy)carbonyl)(methyl)amino)propanoic acid 

Relevant academic research and scientific papers

Small multivalent architectures mimicking homotrimers of the TNF superfamily member CD40L: Delineating the relationship between structure and effector function

Synthetic multivalent ligands, owing to the presence of multiple copies of a recognition motif attached to a central scaffold, can mediate clustering of cell surface receptors and thereby function as effector molecules. This paper dissects the relationship between structure and effector function of synthetic multivalent ligands targeting CD40, a cell surface receptor of the tumor necrosis factor receptor (TNF-R) superfamily. Triggering CD40 signaling in vivo can be used to enhance immunity against intracellular pathogens or tumors. A series of multimeric molecules has been prepared by systematically varying the shape and the valency of the central scaffold, the nature and the length of the linker as well as the sequence of the receptor binding motif. The data reported here (i) suggest that radial distribution of CD40-binding units and C 3-symmetry are preferred for optimal binding to CD40 and signaling, (ii) underscore the importance of choosing an appropriate linker to connect the receptor binding motif to the central scaffold, and (iii) show the versatility of planar cyclic α- and β-peptides as templates for the design of CD40L mimetics. In particular, the (Ahx)3-B trimeric scaffold-linker combination equally accommodated binding elements derived from distinct CD40L hot-spot regions including AA″ loop and β-strand E. The use of miniCD40Ls such as those reported here is complementary to other approaches (recombinant ligands, agonistic anti-receptor antibodies) and may find interesting therapeutic applications. Furthermore, the results disclosed in this paper provide the basis for future design of other TNF family member mimetics.

Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof

A genus of tripeptide amides and fifteen species thereof of Examples 4-18, which are useful as analgesics and/or opiate antagonists, three processes for preparation thereof, pharmaceutical compositions thereof, and the three tripeptide amide species of Examples 1-3, which are not within the genus and are useful as analgesics and/or opiate antagonists, are disclosed.

Analgesic dipeptide amides and method of use and compositions thereof

A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R1 TyrR2 D-AlaNHR4 wherein R1 and R2 are each hydrogen or alkyl provided that at least one of them is other than hydrogen and R4 is phenylalkyl or substituted-phenylalkyl are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.

Assessment of Racemisation in N-Alkylated Amino-acid Derivatives during Peptide Coupling in a Model Dipeptide System

N.m.r. analysis of diastereoisomeric benzoyl dipeptide esters has been used to monitor racemisation during the coupling of benzoyl-N-alkylated amino-acids to alanine and valine methyl esters.Results confirm the greater susceptibility of these amino-acids