68226-08-4

Upstream product

• 3152-68-9 1-phenyl-pent-1-en-3-one 
• 100-52-7 benzaldehyde 
• 78-93-3 butanone 
• 81158-69-2 c-2,c-6-diphenyl-t-3-methyl-r-4-dimethylaminooxane 
• 69291-48-1 cis-2,6-Diphenyl-trans-3-methyloxan-r-4-ol 
• 69291-45-8 trans-2,6-Diphenyl-cis-3-methyloxan-r-4-ol 
• 74854-80-1 c-2,c-6-diphenyl-t-3-methyl-r-4-aminooxane 
• 74854-72-1 t-2,t-6-diphenyl-c-3-methyl-r-4-aminooxane 

Downstream Products

• 67608-74-6 1-methyl-2,4,6,8-tetraphenyl-3-oxa-7-aza-bicyclo[3.3.1]nonan-9-one 
• 74854-67-4 r-2,cis-6-Diphenyl-trans-3-methyl-4-oxanone Oxime 
• 74854-83-4 cis-2,6-diphenyl-trans-3-methyl-4-acetylamino-oxane 
• 74854-76-5 N-((2S,3S,4S,6R)-3-Methyl-2,6-diphenyl-tetrahydro-pyran-4-yl)-acetamide 
• 74854-80-1 c-2,c-6-diphenyl-t-3-methyl-r-4-aminooxane 
• 74854-72-1 t-2,t-6-diphenyl-c-3-methyl-r-4-aminooxane 
• 1227953-32-3 7,9-diphenyl-6-methyl-1,2,4-triaza-8-oxa-spiro(4.5)decan-3-thione 
• 1227953-29-8 C₂₅H₂₅N₃OS 
• 1204707-47-0 C₁₉H₂₁N₃OS 
• 113201-32-4 2-methyl-3,4-diphenyl-cyclopent-3-enone 

Relevant academic research and scientific papers

Spectral characterization and crystal structure of tetrahydropyran-4-one thiosemicarbazones

(E)-1-(Tetrahydro-3-methyl-2,6-diphenylpyran-4-ylidene) thiosemicarbazide (3) and (E)-1-(2,6-bis(4-chlorophenyl)-tetrahydro-3,5-dimethylpyran-4-ylidene) thiosemicarbazide (4) were obtained and characterized by FT-IR, 1H NMR, 13C NMR,

Synthesis, stereochemistry, antimicrobial evaluation and QSAR studies of 2,6-diaryltetrahydropyran-4-one thiosemicarbazones

A series of 2,6-diaryltetrahydropyran-4-one thiosemicarbazones (11-27) were synthesized and characterized for evaluation of potential antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillu

Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro [4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities. Springer Science+Business Media, LLC 2011.

Synthesis, spectral, crystal and antimicrobial studies of biologically potent oxime ethers of nitrogen, oxygen and sulfur heterocycles

Three series of oxime ethers viz, 2,6-diarylpiperidin-4-one O-benzyloximes 5a-o, 2,6-diaryltetrahydropyran-4-one O-benzyloximes 7a-e and 2,6-diaryltetrahydrothiopyran-4-one O-benzyloximes 11a-b and 12a-c were synthesized and stereochemistry is established by their spectral and single crystal analysis. A SAR study has been carried out for the above oxime ethers against a panel of antibacterial (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Escherichia coli) and antifungal agents (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger, Aspergillus flavus and Cryptococcus neoformans), respectively, using Ciprofloxacin and Amphotericin B as standards. Most of the chloro/methyl/methoxy substituted compounds exerted moderate to good activity against all the tested organisms; moreover, some compounds (5i, 5l, 5n, 5o, 7c2, 7d1, 7d2, 7e, 11b and 12c) exhibited promising activity than standard drugs.

Spectral characterization and crystal structure of 5-spiro-(3-methyl-2,6-diphenyltetrahydropyran-4-yl)-4,5-dihydro-[1,3,4]thiadiazole

The synthesis of new 1,3,4-thiadiazoline derived from 3-methyl-2,6-diphenyltetrahydropyran-4-one, via the corresponding thiosemicarbazone, is described. The synthesis, spectral characterization and crystal structure of 5-spiro-1,3,4-thiadiazoline of 2,6-d

Kinetics of oxidation of heterocyclic secondary alcohols by N-chloro-r-2,c-6-diphenyl-t-3 methyl piperidin-4-one (NCP) in perchloric acid medium

An investigation of the kinetics of oxidation of epimeric piperidin-4-ols, oxan-4-ols, and cyclohexanol by N-chloro-r-2, c-6-diphenyl-t-3-methylpiperidin-4-one (NCP) in aqueous acetic acid in the presence of perchloric acid shows that the reaction is first-order each in substrate and oxidant. Both H3O+ and Cl- which catalyze the reaction, exhibit a fractional order kinetics. While increase in ionic strength increases the rate slightly, an inverse dependence is observed between rate and solvent polarity. Addition of r-2-c-6-diphenyl-t-3-methylpiperidin-4-one, one of the reaction products, did not influence the rate. Also, no kinetic isotope effect has been observed. A plausible mechanism consistent with these observations is proposed and the relative reactivities of the substrates are explained on conformational grounds.

Kinetics and mechanism of oxidation of 4-aminooxanes by chromium(VI)

Kinetics of oxidation of variously substituted epimeric pairs of 4-aminooxanes by chromium(VI) have been investigated in aqueous acetic acid in the presence of sulphuric acid.The results indicate that the oxidation is first order in and fractional order in .The reaction is acid catalysed and susceptible to solvent polarity.A mechanism involving the formation of an intermediate followed by abstraction of α-hydrogen in the rate limiting step is proposed.The reactivity of aminooxanes has been discussed on the basis of conformational and electronic effects.Activation parameters have also been determined.

Reactivity of Some Epimeric 4-Aminooxanes towards Oxidation by Cerium(IV)

Kinetics of oxidation of four epimeric pairs of 4-aminooxanes by Ce(IV) in aqueous acetic acid in the presence of nitric acid, have been investigated.The oxidation is first order in .No definite order exists with respect to .A mechanism involving the abstraction of a H-atom from the α-C-H by Ce(IV) in the rate-limiting step is proposed.Equatorial amines react faster than axial amines.Added H(+) or NO3(-) increase the rate of oxidation.Rate is lowered by increase in the polarity of the medium.The conformational (steric) and electronic effects on the rate of oxidation are discussed.

Oxidation of Substituted 1-Hetera-4-cyclohexanols by N-Bromsuccinimide

The rates of NBS oxidation of some substituted 1-hetera-4-cyclohexanols have been measured at 50 deg in 80percent acetic acid-20percent water (v/v).The primary kinetic isotope effect is suggestive of the involvement of C-H or C-D bond of the hydroxy beari

Dissociation Constants of Cyanohydrins of Some Tetrahydropyran-4-ones

The dissociation constants of cyanohydrins of some substituted tetrahydropyran-4-ones have been determined at 30 deg in 80percent dioxane-water (v/v).The results substantiate the steric environment of the carbonyl group in these ketones.