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GW4869 is a synthetic sphingolipid analog that functions as an inhibitor of neutral sphingomyelinase and exosome biogenesis. It has been widely studied for its potential applications in various fields, including cancer research and neuroscience.

6823-69-4

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6823-69-4 Usage

Uses

Used in Cancer Research:
GW4869 is used as an inhibitor of neutral sphingomyelinase and exosome biogenesis for analyzing the effects of arsenic trioxide (ATO) treatment on ceramide production in hepatoma carcinoma HCCLM3 cells. This helps researchers understand the underlying mechanisms of ATO's therapeutic effects on liver cancer.
Used in Neuroscience Research:
GW4869 is used to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)-coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats. This application aids in understanding the molecular pathways involved in pain sensation and the potential therapeutic targets for pain management.

Biochem/physiol Actions

A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)

Check Digit Verification of cas no

The CAS Registry Mumber 6823-69-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,2 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6823-69:
(6*6)+(5*8)+(4*2)+(3*3)+(2*6)+(1*9)=114
114 % 10 = 4
So 6823-69-4 is a valid CAS Registry Number.

6823-69-4 Well-known Company Product Price

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  • Sigma

  • (D1692)  GW4869  ≥90% (NMR)

  • 6823-69-4

  • D1692-5MG

  • 1,910.61CNY

  • Detail

  • Sigma

  • (D1692)  GW4869  ≥90% (NMR)

  • 6823-69-4

  • D1692-25MG

  • 7,084.35CNY

  • Detail

6823-69-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N′-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3′-p-phenylene-bis-acrylamide dihydrochloride

1.2 Other means of identification

Product number -
Other names GW 4869 (hydrochloride hydrate)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6823-69-4 SDS

6823-69-4Upstream product

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