68230-29-5

Upstream product

• 143-33-9 sodium cyanide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 62-53-3 aniline 
• 7677-24-9 trimethylsilyl cyanide 

Relevant academic research and scientific papers

Design and Construction of a Chiral Cd(II)-MOF from Achiral Precursors: Synthesis, Crystal Structure and Catalytic Activity toward C-C and C-N Bond Forming Reactions

Using achiral components, a V-shaped dicarboxylic acid (H2L) and a conformationally flexible bidentate linker (bpp), a thermally stable chiral metal organic framework {[Cd(bpp)(L)(H2O)]·DMF}n (1), where H2L = 4,

A microporous metal-organic framework catalyst for solvent-free strecker reaction and CO2 fixation at ambient conditions

The self-assembly of zinc(II) acetate tetrahydrate, a flexible tetrapyridyl ligand, tetrakis(3-pyridyloxymethylene)methane (3-tpom), a bent dicarboxylic acid, and 4,4′-(dimethylsilanediyl)bis- benzoic acid (H2L) under solvothermal conditions ha

Chiral Cadmium(II) Metal-Organic Framework from an Achiral Ligand by Spontaneous Resolution: An Efficient Heterogeneous Catalyst for the Strecker Reaction of Ketones

A thermally stable cadmium-based chiral metal-organic framework (MOF), {[Cd2(L)(H2O)(DMF)]·3DMF·2H2O}n (1; DMF = N,N-dimethylformamide), has been synthesized from an achiral ligand by spontaneous resolution. The MOF features 1D open channels with a large density of active metal sites and has a 3,6-c binodal net with a rare sit 3,6-conn topology. The metal-bound water and DMF solvents could be easily removed along with the guest molecules in the lattice upon activation to afford the desolvated framework 1′. It exhibits microporous nature, as confirmed by the gas-sorption measurements with carbon dioxide uptake of 43.2 cm3 g-1 at 273 K. The open metal sites in the framework make it an outstanding heterogeneous catalyst in the Strecker reaction for the synthesis of α-aminonitriles in a solvent-free state at room temperature with excellent conversion yields.

Bronsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Bronsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

Fe(Cp)2PF6 catalyzed efficient Strecker reactions of ketones and aldehydes under solvent-free conditions

The synthesis of α-aminonitriles of ketones and aldehydes was performed in very short reaction times (20 min) with excellent yields in the presence of 5 mol % of Fe(Cp)2PF6 under solvent-free conditions.

Synthesis of 4-Hydroxy-2(1H)-pyridones from Azomethines and Substituted Dialkylmalonates

The reaction of azomethines 4 with substituted dialkyl malonates 5 leads to the formation of 3-substituted 4-hydroxy-2(1H)-pyridones 6 in moderate yields. The azomethines 4 are prepared via arylaminopropionitriles 3 or in the conventional way by acid catalyzed condensation of ketones 1 with anilines 2. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 8-10.