682349-66-2

Upstream product

• 100-39-0 benzyl bromide 
• 682349-62-8 N-allyl-N-benzyl-(N'-(2-butynyl))sulfamide 
• 4383-22-6 Allylbenzylamine 
• 682349-60-6 N-allyl-N-benzyl-(N'-tert-butoxycarbonyl-N'-(2-butynyl))sulfamide 

Downstream Products

• 1609242-98-9 dimethyl 2,4-dibenzyl-9-methyl-1,2,4,5,5a,8-hexahydrobenzo[d][1,2,7]thiadiazepine-6,7-dicarboxylate 3,3-dioxide 

Relevant academic research and scientific papers

One-pot ring-closing metathesis-alkene cross metathesis reactions of sulfamide-linked enynes

Ring-closing metathesis (RCM) of sulfamide-linked enynes 7, 11 and 12 containing disubstituted alkynes afforded a series of novel 7-membered cyclic sulfamides 13-15 in good yield. Substrates 5, 9 and 10 containing mono-substituted alkynes gave either simple RCM products 18a-c or those arising from combinations of enyne RCM and olefin cross metathesis 16/17a-c depending on the reaction conditions. Notably, in the presence of two equivalents of styrene or ethyl acrylate, substrates 5, 9 and 10 containing terminal alkynes underwent selective enyne-RCM-olefin-cross metathesis to provide cyclic sulfamides 17a-c and 19b,c in yields of 54-83%. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.