68240-60-8

Upstream product

• 883-90-9 o-benzyl anisole 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 100-39-0 benzyl bromide 
• 22788-49-4 2-methoxyphenyl(phenyl)methanol 

Downstream Products

• 51355-29-4 α-(2-methoxyphenyl)benzeneacetonitrile 
• 1221398-70-4 2-((2-methoxyphenyl)(phenyl)methoxy)isoindoline-1,3-dione 
• 99484-46-5 5-Dimethylamino-2-(2-methoxy-phenyl)-2-phenyl-pentanenitrile 
• 96842-65-8 4-dimethylamino-2-(2-methoxyphenyl)-2-phenylbutanenitrile 
• 96842-80-7 5-dimethylamino-2-(2-hydroxyphenyl)-2-phenylpentanol 
• 99484-32-9 4-dimethylamino-2-(2-hydroxyphenyl)-2-phenylbutanol 
• 96842-89-6 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N,N-dimethylpropylamine 
• 96843-03-7 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-methylpropylamine 
• 96842-82-9 2-(3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylaminoethanamine 
• 96843-02-6 2,3-dihydro-N-methyl-3-phenyl-3-benzofuranethanamine 
• 99484-36-3 3-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylpropylamine 
• 99484-33-0 2-(3-phenyl-2,3-dihydrobenzofuran-3-yl)-N-(2,2,2-trichloroethoxycarbonyl)-N-methylethylamine 
• 99484-55-6 3-(2-oxo-3-phenyl-3-dihydrobenzofuranyl)-N,N-dimethylpropylamine 
• 96842-99-8 3-(2-dimethylamino-ethyl)-3-phenyl-3H-benzofuran-2-one 

Relevant academic research and scientific papers

Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr+-Mes) and N-Chlorosuccinimide

By combining "N-chlorosuccinimide (NCS)"as the safe chlorine source with "Acr+-Mes"as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation. Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor "N-centered succinimidyl radical,"which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr?-Mes.

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi

A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the original compound was superfluous and all early SAR probes led to significant drops in activity. The only alteration that could be achieved without loss of activity was replacement of the aryl chloride substituent with chloro homologues. This led to the discovery of a trifluoromethyl-containing analogue with an EC50 against T. cruzi of 30 nM and a cytotoxicity selectivity index of over 1000 relative to rat skeletal myoblast L-6 cells.

Synthesis and quantitative structure-activity relationships of antibacterial 1-(substituted benzhydryl)-4-(5-nitro-2- furfurylideneamino)piperazines

1-Benzhydryl-4-(5-nitro-2-furfurylideneamino)piperazine and 11 substituted analogs were prepared and examined for in vitro antimicrobial activity. The compounds were active against Bacillus cereus 7, Bacillus megaterium 122, Bacillus subtilis 104, Clostridium perfringens 13, and the tetracycline-resistant Clostridium perfringens 37. Regression analyses on the antibacterial activity data based on the Hansch approach, using π, π2, and σ parameters, yielded several statistically significant correlation equations. 1-Benzhydryl-4-(5-nitro-2-furfurylideneamino)piperazine stopped the protein and DNA syntheses in C. perfringens 13, as indicated by precipitable radioactivity. The compound, however, showed no effect on the cell wall synthesis in the bacteria.