68252-74-4

Basic information

• Product Name: N-[2-chloro-4-(dimethylsulfamoyl)phenyl]acetamide
• CAS NO: 68252-74-4
• Molecular Formula: C₁₀H₁₃ClN₂O₃S
• Molecular Weight: 276.7398
• Mol File: 68252-74-4.mol
• Article Data: 1

Chemical Properties

• Density: 1.383g/cm³
• Refractive Index: 1.579
• CAS DataBase Reference: N-[2-chloro-4-(dimethylsulfamoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-chloro-4-(dimethylsulfamoyl)phenyl]acetamide(68252-74-4)
• EPA Substance Registry System: N-[2-chloro-4-(dimethylsulfamoyl)phenyl]acetamide(68252-74-4)

Safety Data

• Hazardous Substances Data: 68252-74-4(Hazardous Substances Data)

Upstream product

• 16761-18-5 4-acetamido-3-chlorobenzenesulphonyl chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 19021-35-3 4-amino-3-chloro-N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS

The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly 1H-pyrrolo[3,2-c]pyridine-6- amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 – also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)