68254-10-4

Basic information

• Product Name: 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate
• Synonyms: 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate;Fenridazon [iso];1-(4-chlorophenyl)-6-Methyl-4-oxo-1,4-dihydropyridazine-3-carboxylate;1-(4-Chlorophenyl)-1,4-dihydro-6-methyl-4-oxo-3-pyridazinecarboxylic acid
• CAS NO: 68254-10-4
• Molecular Formula: C₁₂H₉ClN₂O₃
• Molecular Weight: 264.66
• Mol File: 68254-10-4.mol

Chemical Properties

• Melting Point: 234.3-235.1℃ (ethanol )
• Boiling Point: 453.4°C at 760 mmHg
• Flash Point: 228°C
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Vapor Pressure: 5.21E-09mmHg at 25°C
• PKA: 0.17±0.20(Predicted)
• CAS DataBase Reference: 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate(68254-10-4)
• EPA Substance Registry System: 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate(68254-10-4)

Safety Data

• Hazardous Substances Data: 68254-10-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate is used as a building block for the synthesis of various pharmaceuticals. Its versatile reactivity and potential biological activity contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate is utilized as a key component in the creation of agrochemicals. Its unique structure and reactivity enable the development of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Material Science:
1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate may also find applications in material science, where its unique properties can be exploited to create novel materials with specific characteristics for various industrial applications.
Used in Organic Chemistry:
1-(4-chlorophenyl)-6-methyl-4-oxo-pyridazine-3-carboxylate is also used in organic chemistry for its potential role in the synthesis of complex organic molecules. Its reactivity and structural features make it a valuable intermediate in the preparation of various organic compounds with diverse applications.

InChI:InChI=1/C12H9ClN2O3/c1-7-6-10(16)11(12(17)18)14-15(7)9-4-2-8(13)3-5-9/h2-6H,1H3,(H,17,18)/p-1

Upstream product

• 541-98-0 6-methyl-pyran-2,4-dione 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 106-47-8 4-chloro-aniline 
• 78242-72-5 C₁₂H₉ClN₂O₃ 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 

Downstream Products

• 83499-25-6 3-Bromopropyl 1-(4-Chlorophenyl)-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylate 
• 80601-23-6 Benzyl 1-(4-Chlorophenyl)-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylate 
• 68253-83-8 methyl 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylate 
• 83499-20-1 Dimethyl 1-(4-Chlorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxamide 

Relevant articles and documents

The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis

A continuous flow process delivering key building blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor emerged as a pivotal technology in both synthesis and isolation phases enabling the processing of slurries and suspensions while maintaining high productivity and reliability. Accordingly, the synthesis of common intermediates in flow were employed to further build a pyridazone-based library (36 compounds) aimed at improving lead compound potency and selectivity while further enabling structure-activity relationship studies of a new BCP modulator family.

Synthesis and in-vitro cytotoxic evaluation of novel pyridazin-4-one derivatives

A new series of N-aryl-4-oxo-1,4-dihydro-pyridazine-3-carboxylic acids has been synthesized by condensation of aryldiazonium with 4-hydroxy-6-methyl-2- pyrone. Some of these compounds exhibited in-vitro cytotoxic activity with moderate to excellent growth

Hybridization of sunflowers and safflowers

A method of inducing male sterility in a dicotyledonous plant which comprises treating the plant prior to, during or post meiosis with an amount of a substituted 4-oxo-1-phenyl-1,4-dihydropyridazine, which is effective to produce male sterility in the plant.

Method of producing hybrid cereal grain seeds by application of 1-aryl-1,4-dihydro-4-oxo(thio)-pyridazines

Compounds of the formula STR1 wherein R1 is aryl or substituted aryl, R2 is alkyl, or aryl, R3 is hydrogen, alkyl, aralkyl, or halogen, or R2 and R3 taken together are --(CH2)n -