6826-24-0

Basic information

• Product Name: 5-PHENYL-OXAZOL-2-YLAMINE
• Synonyms: 5-PHENYL-OXAZOL-2-YLAMINE;5-phenyl-1,3-oxazol-2-amine;5-phenyloxazol-2-amine;2-Amino-5-phenyloxazole;5-Phenyl-2-oxazolamine
• CAS NO: 6826-24-0
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.18
• Mol File: 6826-24-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 215-216℃
• Boiling Point: 341℃
• Flash Point: 160℃
• Appearance: /
• Density: 1.204
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: 5-PHENYL-OXAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-OXAZOL-2-YLAMINE(6826-24-0)
• EPA Substance Registry System: 5-PHENYL-OXAZOL-2-YLAMINE(6826-24-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6826-24-0(Hazardous Substances Data)

Usage

General Description

5-Phenyl-oxazol-2-ylamine is a chemical compound with the molecular formula C10H9N3O. It belongs to the class of molecules known as phenyl-oxazoles, which are organic compounds containing an oxazole ring with a phenyl group attached to it. This chemical is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential applications in medicinal chemistry, particularly in the development of drugs targeting various biological processes. 5-Phenyl-oxazol-2-ylamine is known for its versatile properties and has the potential for various industrial and scientific applications.

Upstream product

• 16927-13-2 α-bromophenylacetaldehyde 
• 57-13-6 urea 
• 122-78-1 phenylacetaldehyde 
• 420-04-2 CYANAMID 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 70-11-1 α-bromoacetophenone 
• 933053-16-8 1-(2-oxo-2-phenylethyl)pyrimidin-2(1H)-one 
• 76758-07-1 5-phenyl-2-<(triphenylmethyl)amino>oxazole 
• 156-62-7 calcium cyanamide 
• 2208-89-1 N-cyanourea 

Downstream Products

• 140685-76-3 benzyl 5-phenyl-2-oxazolethiocarbamate 
• 90831-46-2 1-Phenyl-3-(5-phenyl-oxazol-2-yl)-urea 
• 90831-45-1 1-Methyl-3-(5-phenyl-oxazol-2-yl)-urea 
• 6826-25-1 N-(5-phenyl-oxazol-2-yl)-acetamide 
• 1672-10-2 2-phenyl-oxazolo[3,2-a]pyrimidine-5,7-dione 
• 860542-40-1 N-acetyl-sulfanilic acid-(5-phenyl-oxazol-2-ylamide) 

Relevant articles and documents

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.

Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes

A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).