6826-24-0

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Phenyl-oxazol-2-ylamine is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their efficacy and selectivity for specific biological targets.
Used in Agrochemical Development:
In the agrochemical industry, 5-Phenyl-oxazol-2-ylamine serves as a building block for the creation of new compounds with pesticidal or herbicidal properties. Its incorporation into these products can lead to more effective and environmentally friendly solutions for crop protection.
Used in Medicinal Chemistry Research:
5-Phenyl-oxazol-2-ylamine is employed as a scaffold in medicinal chemistry for the design and development of drugs targeting diverse biological processes. Its structural features make it a promising candidate for the modulation of protein-protein interactions, enzyme activities, and other molecular mechanisms relevant to therapeutic intervention.
Used in Organic Compounds Synthesis:
Beyond its applications in the life sciences, 5-Phenyl-oxazol-2-ylamine is also used in the synthesis of a variety of organic compounds for different industries. Its reactivity and structural attributes make it a valuable component in the creation of specialty chemicals, materials, and other organic products.

Upstream product

• 70-11-1 α-bromoacetophenone 
• 16927-13-2 α-bromophenylacetaldehyde 
• 57-13-6 urea 
• 122-78-1 phenylacetaldehyde 
• 420-04-2 CYANAMID 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 933053-16-8 1-(2-oxo-2-phenylethyl)pyrimidin-2(1H)-one 
• 76758-07-1 5-phenyl-2-<(triphenylmethyl)amino>oxazole 
• 156-62-7 calcium cyanamide 
• 2208-89-1 N-cyanourea 

Downstream Products

• 860542-40-1 N-acetyl-sulfanilic acid-(5-phenyl-oxazol-2-ylamide) 
• 90831-45-1 1-Methyl-3-(5-phenyl-oxazol-2-yl)-urea 
• 90831-46-2 1-Phenyl-3-(5-phenyl-oxazol-2-yl)-urea 
• 140685-76-3 benzyl 5-phenyl-2-oxazolethiocarbamate 
• 6826-25-1 N-(5-phenyl-oxazol-2-yl)-acetamide 
• 1672-10-2 2-phenyl-oxazolo[3,2-a]pyrimidine-5,7-dione 

Relevant academic research and scientific papers

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Amido Compounds

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein the variables are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.

Synthesis and reactions of N-o-anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethylcarbodiimides with aldehydes

N-o-Anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethyl-carbodiimides (2) and (3) have been synthesized from the corresponding sulfinic acids by Mannich reaction. 2 and 3 are useful synthons in two step synthesis of 2-amino-1,3-oxazoles(4).

Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes

A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).