682770-47-4Relevant academic research and scientific papers
Synthesis method of 3-carbonyl 5-hydroxyl ester compound
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Paragraph 0029-0032; 0081-0086, (2021/05/29)
The invention discloses a novel synthesis method of a 3-carbonyl 5-hydroxyl ester compound with a structure as shown in a formula (1) defined in the description, which comprises the steps of taking a common carbon-based compound with a structure as shown in a formula (2) defined in the description and a polycarbonyl dicarboxylic acid unilateral ester compound (3) as raw materials, and directly and fully reacting in an organic solvent A under the condition of a transition metal catalyst, separating and purifying the reaction system after the reaction to obtain 3-carbonyl-5-hydroxy ester compound with high yield and high selectivity.
Synthesis of multifunctionalized building blocks via vinylogous addition of Chan's diene to carbonyl and carbonyl-related electrophiles, mediated by molecular iodine
Villano, Rosaria,Acocella, Maria R.,Scettri, Arrigo
experimental part, p. 2768 - 2772 (2011/04/27)
The synthesis of multifunctionalized β-ketoesters has been achieved by using molecular iodine as a catalyst under very mild conditions. The vinylogous addition of Chan's diene 1 to carbonyl and carbonyl-related compounds (aldehydes, ketones, imines and acetals) occurred with high efficiencies and with complete γ-selectivity, giving a useful method for the synthesis of interesting libraries of different δ-functionalized β-ketoesters.
Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates
Xu, Chengfu,Yuan, Chengye
, p. 2169 - 2186 (2007/10/03)
A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.
A Chemoenzymatic Approach to Optically Active 5-Hydroxy-3-oxocarboxylates
Xu, Chengfu,Zhang, Yonghui,Yuan, Chengye
, p. 485 - 488 (2007/10/03)
Enzymatic hydrolysis was applied to the preparation of certain chiral 5-hydroxy-3-oxo-carboxylates that are potential precursors for natural product synthesis via the formation of lactone derivatives and tetrahydropyran rings.
