682772-24-3Relevant academic research and scientific papers
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction
Pissarnitski, Dmitri A.,Asberom, Theodros,Boyle, Craig D.,Chackalamannil, Samuel,Chintala, Madhu,Clader, John W.,Greenlee, William J.,Hu, Yueqing,Kurowski, Stanley,Myers, Joyce,Palamanda, Jairam,Stamford, Andrew W.,Vemulapalli, Subbarao,Wang, Yuguang,Wang, Peng,Wu, Ping,Xu, Ruo
, p. 1291 - 1294 (2004)
Development of structure-activity relationship of cyclic guanines I lead us to discovery of a potent and selective series of phosphodiesterase 5 inhibitors 52-59 (IC50=1.3-11.0 nM, PDE6/5=116-600).
