682777-22-6

Basic information

• Product Name: 2-Propyn-1-amine, N,N-diethyl-3-(4-nitrophenyl)-
• CAS NO: 682777-22-6
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.282
• Mol File: 682777-22-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-amine, N,N-diethyl-3-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-amine, N,N-diethyl-3-(4-nitrophenyl)-(682777-22-6)
• EPA Substance Registry System: 2-Propyn-1-amine, N,N-diethyl-3-(4-nitrophenyl)-(682777-22-6)

Safety Data

• Hazardous Substances Data: 682777-22-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 109-89-7 diethylamine 
• 636-98-6 p-nitrobenzene iodide 
• 106-96-7 propargyl bromide 
• 4079-68-9 N,N-diethyl-2-propynylamine 
• 586-78-7 para-nitrophenyl bromide 

Relevant articles and documents

Tandem amine propargylation-Sonogashira reactions: New three-component coupling leading to functionalized substituted propargylic amines

Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium-copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to

Alkynylation of aryl bromides with propargylamines catalyzed by a palladium-tetraphosphine complex

The tetraphosphine all-cis-1,2,3,4-tetrakis(diphenylphosphinomethyl) cyclopentane in combination with [Pd(C3H5)Cl]2 affords a very efficient catalyst for the alkynylation of aryl bromides with propargylamines. Higher reactions rates were observed with N,N- dialkylpropargylamines than with N-methylpropargylamine or propargy lamine. A wide variety of substituents such as alkyl, phenyl, methoxy, dimethylamino, fluoro, trifluoromethyl, acetyl, benzoyl, formyl, carboxylate, nitro, or nitrile, on the aryl bromides are tolerated. High turnover numbers can be obtained with most of these aryl bromides. The coupling reaction of sterically very congested aryl bromides such as 9-bromoanthracene or 2,4,6- triisopropylbromobenzene also proceeds in good yields. Georg Thieme Verlag Stuttgart.