682804-73-5

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-3-(3,5-DIFLUORO-PHENYL)-PROPIONIC ACID is used as a building block for the synthesis of various drugs and biologically active molecules, contributing to the development of new therapeutic agents.
Used in Chemical Research:
In the realm of chemical research, 3-AMINO-3-(3,5-DIFLUORO-PHENYL)-PROPIONIC ACID is utilized as a reagent and intermediate, playing a crucial role in the preparation of other compounds, thereby facilitating advancements in chemical synthesis and compound development.

Upstream product

• 141-82-2 malonic acid 
• 32085-88-4 3,5-difluorobenzaldehyde 

Downstream Products

• 927406-05-1 C₁₁H₈F₅NO₃ 
• 790227-45-1 C₉H₁₁F₂NO 

Relevant academic research and scientific papers

1-PHENYLPYRROLIDIN-2-ONE DERIVATIVES AS PERK INHIBITORS

The invention is directed to substituted pyrrolidinone and imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases/injuries associated with activated unfolded protein response pathways, such as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson's disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt- Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

GAMMA SECRETASE MODULATORS

In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

CHEMICAL COMPOUNDS

The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i),formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6-CR7R8, O-CR7R