68295-45-4 Usage
Uses
Used in Pharmaceutical Industry:
(R)-(-)-2-(ANILINOMETHYL)PYRROLIDINE is used as a chiral auxiliary for the synthesis of various pharmaceutical compounds. Its ability to influence the stereochemistry of reactions makes it a valuable tool in the development of enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Analytical Chemistry:
(R)-(-)-2-(ANILINOMETHYL)PYRROLIDINE is used as a reagent for determining the absolute configuration of amines and α-amino acids by 1H NMR of (R)-O-aryllactic acid amides. This application is crucial in the field of analytical chemistry, as it helps researchers and chemists to accurately determine the stereochemistry of these important biomolecules, which is often critical for their biological activity and function.
Check Digit Verification of cas no
The CAS Registry Mumber 68295-45-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,9 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68295-45:
(7*6)+(6*8)+(5*2)+(4*9)+(3*5)+(2*4)+(1*5)=164
164 % 10 = 4
So 68295-45-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2/c1-2-5-10(6-3-1)13-9-11-7-4-8-12-11/h1-3,5-6,11-13H,4,7-9H2/t11-/m1/s1
68295-45-4Relevant academic research and scientific papers
Potent and selective nonpeptide inhibitors of caspases 3 and 7
Lee,Long,Murray,Adams,Nuttall,Nadeau,Kikly,Winkler,Sung,Ryan,Levy,Keller,DeWolf Jr.
, p. 2015 - 2026 (2007/10/03)
5-Dialkylaminosulfonylisatins have been identified as potent, nonpeptide inhibitors of caspases 3 and 7. The most active compound within this series (34) inhibited caspases 3 and 7 in the 2-6 nM range and exhibited approximately 1000-fold selectivity for caspases 3 and 7 versus a panel of five other caspases (1, 2, 4, 6, and 8) and was at least 20-fold more selective versus caspase 9. Sequence alignments of the active site residues of the caspases strongly suggest that the basis of this selectivity is due to binding in the S2 subsite comprised of residues Tyr204, Trp206, and Phe256 which are unique to caspases 3 and 7. These compounds inhibit apoptosis in three cell-based models: human Jurkat T cells, human chondrocytes, and mouse bone marrow neutrophils.
