68301-05-3

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 754207-98-2 2,4-dichloro-6-[N-(4'-ethoxyphenyl)dithiocarbamoyl]-s-triazine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 

Downstream Products

• 1084910-30-4 C₂₇H₂₆N₆OS₄ 
• 77576-56-8 2-chloro-4-(4-ethoxyanilino)-6-(isonicotinylhydrazino)-s-triazine 

Relevant academic research and scientific papers

Simple and efficient synthetic routes to bioactive s-triazinyl dithiocarbamate derivatives

Series of 2,4-diarylamino-6-[N-(3′-methylphenyl)dithiocarbamoyl]-s- triazines (4a-l) and 2,4-bis[N-(3′-methylphenyl)dithiocarbamoyl]-6- arylamino-s-triazines (7a-l) were synthesized by two different synthetic routes. In the first route (A), 2,4,6-tricholoro-s-triazine (1) was condensed with N-(3-methylphenyl)ammoniumdithiocarbamate to afford compounds 3 or 6, which on reaction with different aryl amines afforded compounds 4a-l or 7a-l. In the second route (B), condensation of 1 with different aryl amines yielded compounds 2a-l or 5a-l. On further treatment with N-(3-methylphenyl) ammoniumdithiocarbamate these afforded compounds 4a-l or 7a-l. The newly synthesized compounds 4a-l and 7a-l were characterized by elemental analyses, infrared (IR), and 1H nuclear magnetic resonance (NMR) spectroscopic investigation. All the products were evaluated for their antibacterial and antifungal activity.

Simple and efficient synthetic routes to s-triazinyl dithiocarbamate derivatives: 2,4-Diarylamino-6-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-s-triazines and 2,4-bis-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-6-arylamino-s-triazines

Compounds 2,4-diarylamino-6-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-s-triazines 4a-f and 2,4-bis-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-6-arylamino-s-triazines 7a-f have been synthesized by two different methods. In the first method (A) of preparation, 2,4,6-trichloro-s-triazine 1 is condensed with N-(4-ethoxyphenyl)ammoniumdithiocarbamate to afford 3 or 6 followed by the reaction with arylamines to afford 4a-f or 7a-f. In the second method (B) of preparation, 1 is condensed with arylamines to yield 2a-f or 5a-f followed by the action of N-(4-ethoxyphenyl)ammoniumdithiocarbamates to yield 4a-f or 7a-f. The constitutions of newly synthesised compounds 4a-f and 7a-f have been established on the basis of elemental analyses, IR and PMR spectral data. Antimicrobial activity of compounds 4a-f and 7a-f are performed by using cup-plate method against gram-positive bacteria, gram-negative bacteria and antifungal fungi. All the synthesised compounds have shown significant antimicrobial activity.