6832-03-7Relevant academic research and scientific papers
NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS
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Paragraph 0412, (2018/03/25)
The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.
Mechanisms of Bromination of Uracil Derivatives. 5. Reaction of Uracil and 5-Bromouracil via Their Anions in Weakly Acidic Aqueous Solution
Tee, Oswald S.,Berks, Charles G.
, p. 830 - 835 (2007/10/02)
The rates of reaction of bromine with uracil, 1-methyluracil, 3-methyluracil, 1,3-dimethyluracil, 5-bromouracil, and 5-bromo-1,3-dimethyluracil have been measured in acidic, aqueous solutions (pH 0-5).For those derivatives having a methyl group at N1 the observed second-order rate constants are invariant with acidity, whereas for those derivatives having hydrogen at N1 they increase with decreasing acidity.These results suggest that reaction upon the anions of uracil, 3-methyluracil, and 5-bromouracil predominates at higher pH.The mechanistic implications of these findings are discussed.
