61686-79-1Relevant academic research and scientific papers
Palladium-catalyzed direct arylation of 5-halouracils and 5-halouracil nucleosides with arenes and heteroarenes promoted by TBAF
Liang, Yong,Gloudeman, Jennifer,Wnuk, Stanislaw F.
, p. 4094 - 4103 (2014/05/20)
The 1-N-benzyl-5-iodo(or bromo)uracil undergoes Pd-catalyzed [Pd 2(dba)3] direct arylation with benzene and other simple arenes in the presence of TBAF in DMF without the necessity of adding any ligands or additives to give 5-arylate
HSAB driven chemoselectivity in alkylation of uracil derivatives. A high yielding preparation of 3-alkylated and unsymmetrically 1,3-dialkylated uracils
Gambacorta, Augusto,Farah, Mohamed Elmi,Tofani, Daniela
, p. 12615 - 12628 (2007/10/03)
A qualitative hardness scale (N134) has been found for the conjugated bases of 2-methoxy-4(3H)-pyrimidinones 1-3 and applied to high yielding chemoselective N3 methylation, ethylation and benzylation reactions. Removal of the 2-methoxy group followed by a second alkylation affords unsymmetrically 1,3-disubstituted uracils.
REDUCTIVE DEBROMINATION OF 5-BROMOURACILS BY 1-BENZYL-1,4-DIHYDRONICOTINAMIDE
Sako, Magoichi,Hirota, Kosaku,Maki, Yoshifumi
, p. 3919 - 3922 (2007/10/02)
N(1)-Unsubstituted 5-bromouracils with or without a substituent in position 6 undergo reductive debromination with ease most likely via a one-electron transfer process upon treatment with 1-benzyl-1,4-dihydronicotinamide under thermal conditions.
