683223-08-7Relevant academic research and scientific papers
1-acylsemicarbazides by ring opening of iminodiaziridines with carboxylic acids: Novel, expeditious access to the azapeptide motif
Quast, Helmut,Schmitt, Edeltraud,Ross, Karl-Heinz
experimental part, p. 3358 - 3362 (2010/11/16)
Carboxylic acids react rapidly and quantitatively with iminodiaziridines to afford 1,2,4-trisubstituted 1-acylsemicarbazides in a multistep sequence. In this way, a carboxy group is readily converted into an azapeptide motif. Broad signals in high-field H and C NMR spectra recorded for the products are indicative of dynamic processes. Georg Thieme Verlag Stuttgart New York.
