683239-16-9

Basic information

• Product Name: 20-(tert-Butoxy)-20-oxoicosanoic acid
• Synonyms: 20-(tert-Butoxy)-20-oxoicosanoic acid;20-(tert-Butoxy)-20-Eicosanedioic Acid;Eicosandioic acid, 1-(1,1-dimethyl) ester
• CAS NO: 683239-16-9
• Molecular Formula: C₂₄H₄₆O₄
• Molecular Weight: 398.61964
• Mol File: 683239-16-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 496.0±18.0 °C(Predicted)
• Appearance: /
• Density: 0.942±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 20-(tert-Butoxy)-20-oxoicosanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 20-(tert-Butoxy)-20-oxoicosanoic acid(683239-16-9)
• EPA Substance Registry System: 20-(tert-Butoxy)-20-oxoicosanoic acid(683239-16-9)

Safety Data

• Hazardous Substances Data: 683239-16-9(Hazardous Substances Data)

Usage

Description

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and in the synthesis of PROTACs.

Uses

20-(tert-Butoxy)-20-oxoicosanoic acid is a useful research chemical compound.

Upstream product

• 2424-92-2 octadecane-1,18-dicarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1644575-06-3 10-bromodecanoic acid tert-butyl ester 
• 50530-12-6 10-bromodecanoic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 101702-50-5 1,20-eicosanedioyl dichloride 

Downstream Products

• 1642333-05-8 docosanedioic acid mono-tert-butyl ester 
• 1642333-07-0 20-bromo-icosanoic acid tert-butyl ester 

Relevant articles and documents

Preparation method of long-chain aliphatic dicarboxylic acid mono-tert-butyl ester

The invention provides a method for obtaining the long-chain aliphatic dicarboxylic acid mono-tert-butyl ester through monohydrolysis of the long-chain aliphatic dicarboxylic acid di-tert-butyl ester by controlling the reaction conditions of monohydrolysis; and the raw material cost is low, the yield is high, the post-treatment method is simple, and the method is suitable for industrial production.

A process for preparing a fatty acid derivative method and its application (by machine translation)

The invention discloses a method for preparing a fatty acid derivative method and its application. The first method is the long-chain fatty acid and thionyl chloride reaction, to obtain the acyl chloride; acyl chloride of preparing butanol reaction, then remove chlorine group, and get long-chain fatty acid uncle ding zhi; then and N - hydroxysuccinimide reaction, long-chain fatty acid succinimide and high yield butylacrylate; then with the L - glutamic acid - 1 - tert-butyl reaction, to obtain tert-butyl long-chain fatty acyl - L - Glu - OtBu; with the N - hydroxysuccinimide reaction, to obtain tert-butyl long-chain fatty acyl - L - Glu (OSu)- OtBu; finally [...] butyl long-chain fatty acyl - L - Glu (OSu)- OtBu tert-butyl in removing, and get long-chain fatty acid derivatives. The method routes the operation is simple, quality is controllable, is suitable for industrial production, and low cost, simple purification at the same time, suitable for use in the preparation of high purity insulin analogs. (by machine translation)

GLP-2 compounds, formulations, and uses thereof

The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.