1644575-06-3

Basic information

• Product Name: 10-bromodecanoic acid tert-butyl ester
• CAS NO: 1644575-06-3
• Molecular Weight: 307.271
• Mol File: 1644575-06-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 10-bromodecanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 10-bromodecanoic acid tert-butyl ester(1644575-06-3)
• EPA Substance Registry System: 10-bromodecanoic acid tert-butyl ester(1644575-06-3)

Safety Data

• Hazardous Substances Data: 1644575-06-3(Hazardous Substances Data)

Usage

Type of compound

Tert-butyl ester derivative of 10-bromodecanoic acid

Fatty acid

10-bromodecanoic acid

Usage

Organic synthesis and chemical research

Physical state

Colorless, oily liquid

Odor

Faint

Solubility

Soluble in organic solvents such as ethanol and acetone

Applications

Pharmaceutical and agricultural industries

Role

Precursor for the synthesis of various pharmaceuticals and pesticides

Importance

Crucial in the production of a wide range of chemical products and research applications

Upstream product

• 50530-12-6 10-bromodecanoic acid 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 75-65-0 tert-butyl alcohol 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 683239-16-9 eicosanedioic acid mono(1,1-dimethylethyl)ester 
• 2424-92-2 octadecane-1,18-dicarboxylic acid 
• 1767-98-2 20-methoxy-20-oxoicosanoic acid 

Relevant articles and documents

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Preparation method of long-chain aliphatic dicarboxylic acid mono-tert-butyl ester

The invention provides a method for obtaining the long-chain aliphatic dicarboxylic acid mono-tert-butyl ester through monohydrolysis of the long-chain aliphatic dicarboxylic acid di-tert-butyl ester by controlling the reaction conditions of monohydrolysis; and the raw material cost is low, the yield is high, the post-treatment method is simple, and the method is suitable for industrial production.

A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein–Protein Conjugates

Bioorthogonal chemistry holds great potential to generate difficult-to-access protein–protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts, or often do not result in quantitative product formation. Here we present a highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels–Alder cycloaddition with inverse electron demand (DAinv). With the aim of precisely generating branched protein chimeras, we systematically assessed the reactivity, stability and side product formation of various bioorthogonal chemistries directly at the protein level. We demonstrate the efficiency and versatility of our conjugation platform using different functional proteins and the therapeutic antibody trastuzumab. This technology enables fast and routine access to tailored and hitherto inaccessible protein chimeras useful for a variety of scientific disciplines. We expect our work to substantially enhance antibody applications such as immunodetection and protein toxin-based targeted cancer therapies.